Journal article
MIBG and somatostatin receptor analogs in children: current concepts on diagnostic and therapeutic use
The Journal of nuclear medicine (1978), Vol.46 Suppl 1(1 suppl), pp.55S-61S
01/2005
PMID: 15653652
Abstract
Nuclear imaging techniques such as bone scans, metaiodobenzylguanidine (MIBG) scans, and (111)In-diethylenetriaminepentaacetic acid-octreotide scans have greatly increased the sensitivity and specificity of both diagnostic and follow-up protocols for pediatric solid tumors. Molecular targets that are specific for certain pediatric tumors are now being developed. Targets include cell membrane receptors targeted by specific ligands, subcellular organelles targeted by false transmitters, and cellular proteins targeted by antibodies. This review focuses on the use of MIBG (which is a false transmitter) and octreotide (which is a ligand for G protein receptor) in the diagnosis and treatment of solid tumors that affect children and young adults.
Details
- Title: Subtitle
- MIBG and somatostatin receptor analogs in children: current concepts on diagnostic and therapeutic use
- Creators
- Farzana D Pashankar - Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USAM Sue O'DorisioYusuf Menda
- Resource Type
- Journal article
- Publication Details
- The Journal of nuclear medicine (1978), Vol.46 Suppl 1(1 suppl), pp.55S-61S
- Publisher
- United States
- PMID
- 15653652
- ISSN
- 0161-5505
- eISSN
- 1535-5667
- Language
- English
- Date published
- 01/2005
- Academic Unit
- Radiology; Stead Family Department of Pediatrics; Radiation Oncology
- Record Identifier
- 9984047865302771
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