Journal article
MODULATION OF MECHANOTRANSDUCTION IN AORTIC BARORECEPTOR NEURONS
Fundamental & clinical pharmacology, Vol.11(S1), pp.58s-63s
12/1997
DOI: 10.1111/j.1472-8206.1997.tb00877.x
Abstract
We have developed a BRN preparation from nodose ganglia of rats which allowed us to study the ionic mechanisms that determine BR activity. Our findings suggest that SACs may be the mechanoelectrical transducers of BRs, generating a potential at the nerve endings in response to changes in arterial pressure. Defects in the SACs may underlie fundamental pathologic abnormalities. The putative paracrine modulators of BR activity in vivo (prostacyclin and NO) have specific effects on the ion channels which are predominant in the spike initiating zone of BR nerve endings. Prostacyclin, which increases BR activity, blocks Ca2+-dependent K+ channels and increases membrane excitability through a cAMP-G protein-PKA-dependent process. In contrast NO, which suppresses BR activity, blocks NA+ channels through a cGMP-independent mechanism. The possible alteration of mechanosensitivity by these ionic events will be explored further in the isolated preparation.
Details
- Title: Subtitle
- MODULATION OF MECHANOTRANSDUCTION IN AORTIC BARORECEPTOR NEURONS
- Creators
- F.M. Abboud - Veterans Health AdministrationM.W. Chapleau - Veterans Health Administration
- Resource Type
- Journal article
- Publication Details
- Fundamental & clinical pharmacology, Vol.11(S1), pp.58s-63s
- Publisher
- Blackwell Publishing Ltd
- DOI
- 10.1111/j.1472-8206.1997.tb00877.x
- ISSN
- 0767-3981
- eISSN
- 1472-8206
- Number of pages
- 6
- Language
- English
- Date published
- 12/1997
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984297508802771
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