MOLECULAR-BASIS OF COOPERATIVITY IN VERTEBRATE MUSCLE THIN-FILAMENTS

P W Brandt; M S Diamond; B Gluck; M Kawai; F Schachat

doi:10.1007/BF02913943

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MOLECULAR-BASIS OF COOPERATIVITY IN VERTEBRATE MUSCLE THIN-FILAMENTS

Journal article

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MOLECULAR-BASIS OF COOPERATIVITY IN VERTEBRATE MUSCLE THIN-FILAMENTS

P W Brandt, M S Diamond, B Gluck, M Kawai and F Schachat

Carlsberg research communications, Vol.49(2), pp.155-167

01/01/1984

DOI: 10.1007/BF02913943

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Abstract

Extraction of as little as one troponin C per regulatory strand on a thin filament reduces the slope of the pCa/tension relation thus the regulatory units along a thin filament of rabbit psoas fibers are linked cooperatively so that a thin filament activates as a unit. This explains why the pCa/tension relation in skinned fibers has a slope much higher than can be expected by binding of Ca2+ to one regulatory unit (Brandt et al. 1980;Brandt et al. 1982). These results also show that troponin C is the only myfibrillar component responsible for calcium sensitivity in psoas muscle. © 1984 Carlsberg Laboratory.

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Title: Subtitle: MOLECULAR-BASIS OF COOPERATIVITY IN VERTEBRATE MUSCLE THIN-FILAMENTS
Creators: P W Brandt - Columbia University
M S Diamond - Columbia University
B Gluck - Columbia University
M Kawai - Columbia University
F Schachat - Duke University
Resource Type: Journal article
Publication Details: Carlsberg research communications, Vol.49(2), pp.155-167
DOI: 10.1007/BF02913943
ISSN: 0105-1938
Publisher: Springer Nature
Number of pages: 13
Language: English
Date published: 01/01/1984
Academic Unit: Anatomy and Cell Biology; Internal Medicine
Record Identifier: 9984284360202771

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