Journal article
MR Imaging Volumetry of Subcortical Structures and Cerebellar Hemispheres in Normal Persons
American journal of neuroradiology : AJNR, Vol.24(4), pp.644-647
04/2003
PMID: 12695196
Abstract
BACKGROUND AND PURPOSE:
Volume changes in subcortical structures and cerebella have been associated with localization-related epilepsy and psychiatric illnesses. This study evaluated the effect of handedness and sex on the volumes of selected subcortical structures and cerebellar hemispheres in normal persons.
METHODS:
Volumetric measurements were performed of the caudate heads, thalami, and cerebellar hemispheres in 34 (20 right- and 14 left-handed, 19 female and 15 male) normal persons. Amygdalar and hippocampal volumes were reported previously for these persons. All study participants completed a 10-item handedness questionnaire. The MR imaging sequence was a 3D T1-weighted gradient-echo acquisition of the whole brain (24/6 [TR/TE]; flip angle, 25 degrees). MR images were spatially normalized, and volumes were painted with a 1.0 mm
3
resolution cursor on an SGI workstation. The effects of handedness and sex on standardized volumes and right-to-left volume ratios were calculated, and volumes were compared between right and left sides for each structure.
RESULTS:
Handedness did not affect standardized volumes or asymmetries of the caudate heads, thalami, or cerebellar hemispheres. The volumes of subcortical structures were bilaterally larger in women than in men. Right-to-left asymmetries were significant for the caudate head and cerebellum but not for the thalamus.
CONCLUSION:
These findings show that women have significantly larger subcortical structures than do men after spatial normalization to account for differences in brain size. Sex-specific normal ranges may be needed for evaluating volume changes related to epilepsy or other disease processes.
Details
- Title: Subtitle
- MR Imaging Volumetry of Subcortical Structures and Cerebellar Hemispheres in Normal Persons
- Creators
- C. Ákos Szabó - Division of Neurology, University of Texas Health Science Center at San Antonio, San Antonio, TXJack L Lancaster - Research Imaging Center, University of Texas Health Science Center at San Antonio, San Antonio, TXJinhu Xiong - Research Imaging Center, University of Texas Health Science Center at San Antonio, San Antonio, TXChristopher Cook - Research Imaging Center, University of Texas Health Science Center at San Antonio, San Antonio, TXPeter Fox - Division of Neurology, University of Texas Health Science Center at San Antonio, San Antonio, TX
- Resource Type
- Journal article
- Publication Details
- American journal of neuroradiology : AJNR, Vol.24(4), pp.644-647
- Publisher
- American Society of Neuroradiology
- PMID
- 12695196
- ISSN
- 0195-6108
- eISSN
- 1936-959X
- Language
- English
- Date published
- 04/2003
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering
- Record Identifier
- 9984083253302771
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