Journal article
MRI-assessed Dynamic Hyperinflation Induced by Tachypnea in Chronic Obstructive Pulmonary Disease: The SPIROMICS-HF Study
Radiology. Cardiothoracic imaging, Vol.7(1), e240053
02/01/2025
DOI: 10.1148/ryct.240053
PMCID: PMC11880862
PMID: 39836055
Abstract
Purpose
To assess the repeatability of real-time cine pulmonary MRI measures of metronome-paced tachypnea (MPT)–induced dynamic hyperinflation and its relationship with chronic obstructive pulmonary disease (COPD) severity.
Materials and Methods
SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS) (ClinicalTrials.gov identifier no. NCT01969344) is a multicenter prospective cohort study that recruited individuals with COPD with 20 or more pack-years smoking history and controls aged 40–80 years. SPIROMICS-HF is a cross-sectional study evaluating cardiopulmonary interactions in COPD from December 2019 to April 2024. Two-dimensional coronal real-time cine pulmonary MRI (3.2 frames/sec) was performed during MPT twice. Lung masks and lung MR images from an independent study were used for transfer learning to segment real-time cine pulmonary MR images. Dynamic hyperinflation was evaluated as the increase in end-expiratory lung volume (EELV) during tidal breathing to the end of MPT. Repeatability was assessed with intraclass correlation coefficients, and multivariable associations with COPD severity were examined.
Results
Of the 70 participants (mean age, 67 years ± 10 [SD]; 37 male, 33 female) included in the study, 59% had COPD. The transfer learning model achieved high accuracy in lung segmentation (Dice similarity coefficient, 0.94 ± 0.03). There was good scan-rescan agreement for EELV and dynamic hyperinflation (intraclass correlation coefficient, 0.99 and 0.87, respectively). Dynamic hyperinflation was associated with COPD severity (P trend = .01, with a mean difference between severe COPD and controls of 0.24 L).
Conclusion
A transfer learning model yielded reproducible quantification of MPT-induced dynamic hyperinflation at real-time cine pulmonary MRI, with greater dynamic hyperinflation in participants with more severe COPD.
Details
- Title: Subtitle
- MRI-assessed Dynamic Hyperinflation Induced by Tachypnea in Chronic Obstructive Pulmonary Disease: The SPIROMICS-HF Study
- Creators
- Xuzhe Zhang - Columbia UniversityChristopher B. Cooper - University of California, Los AngelesMartin R. Prince - Weill Cornell MedicineBharath Ambale-Venkatesh - Johns Hopkins UniversityPrachi P. Agarwal - University of MichiganMichael C. Backman - Columbia University Irving Medical CenterDavid A. Bluemke - University of Wisconsin–MadisonDavid Couper - University of North Carolina at Chapel HillStephen M. Dashnaw - Columbia University Irving Medical CenterJohn P. Finn - University of California, Los AngelesNadia N. Hansel - Johns Hopkins UniversityEric A. Hoffman - University of IowaSachin Jambawalikar - Columbia University Irving Medical CenterDalane W. Kitzman - Wake Forest UniversityJerry A. Krishnan - University of Illinois ChicagoYoo Jin Lee - University of California, San FranciscoJoão A. C. Lima - Johns Hopkins UniversityJing Liu - University of California, San FranciscoMartha G. Menchaca - University of Illinois ChicagoJill Ohar - Wake Forest UniversityVictor E. Ortega - Mayo Clinic HospitalRobert Paine - University of UtahStephen P. Peters - Wake Forest UniversityJoyce D. Schroeder - Mayo ClinicJens Vogel-Claussen - Medizinische Hochschule HannoverPrescott G. Woodruff - University of California, San FranciscoR. Graham Barr - Columbia University Irving Medical CenterWei Shen - Columbia University Irving Medical Center
- Resource Type
- Journal article
- Publication Details
- Radiology. Cardiothoracic imaging, Vol.7(1), e240053
- DOI
- 10.1148/ryct.240053
- PMID
- 39836055
- PMCID
- PMC11880862
- NLM abbreviation
- Radiol Cardiothorac Imaging
- ISSN
- 2638-6135
- eISSN
- 2638-6135
- Publisher
- RADIOLOGICAL SOC NORTH AMERICA (RSNA); OAK BROOK
- Grant note
- National Institutes of Health (NIH) /National Heart, Lung, and Blood Institute (NHLBI) grants: R01-HL093081, R01-HL121270 NIH/NHLBI: HHSN268200900013C, HHSN268200900014C, HHSN268200900015C, HHSN268200900016C, HHSN268200900017C, HHSN268200900018C, HHSN268200900019C, HHSN268200900020C
Supported by the National Institutes of Health (NIH) /National Heart, Lung, and Blood Institute (NHLBI) grants R01-HL093081 and R01-HL121270. The Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS) was supported by contracts from the NIH/NHLBI (nos. HHSN268200900013C, HHSN268200900014C, HHSN268200900015C, HHSN268200900016C, HHSN268200900017C, HHSN268200900018C, HHSN268200900019C, and HHSN268200900020C) , which were supplemented by contributions made through the Foundation for the NIH from AstraZeneca, Bellerophon Therapeutics, Boehringer Ingelheim Pharmaceuticals, Chiesi Farmaceutici, Forest Research Institute, GSK, Grifols Therapeutics, Ikaria, Nycomed, Takeda Pharmaceutical, Novartis Pharmaceuticals, Regeneron Pharmaceuticals, and Sanofi.
- Language
- English
- Date published
- 02/01/2025
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
- Record Identifier
- 9984775015502771
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