MRI in Multiple Sclerosis: What’s Inside the Toolbox?

Mohit Neema; James Stankiewicz; Ashish Arora; Zachary D. Guss; Rohit Bakshi

doi:10.1016/j.nurt.2007.08.001

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MRI in Multiple Sclerosis: What’s Inside the Toolbox?

Journal article

Open access

Peer reviewed

MRI in Multiple Sclerosis: What’s Inside the Toolbox?

Mohit Neema, James Stankiewicz, Ashish Arora, Zachary D. Guss and Rohit Bakshi

Neurotherapeutics, Vol.4(4), pp.602-617

10/01/2007

DOI: 10.1016/j.nurt.2007.08.001

PMCID: PMC7479680

PMID: 17920541

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https://doi.org/10.1016/j.nurt.2007.08.001View

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Abstract

Magnetic resonance imaging (MRI) has played a central role in the diagnosis and management of multiple sclerosis (MS). In addition, MRI metrics have become key supportive outcome measures to explore drug efficacy in clinical trials. Conventional MRI measures have contributed to the understanding of MS pathophysiology at the macroscopic level yet have failed to provide a complete picture of underlying MS pathology. They also show relatively weak relationships to clinical status such as predictive strength for clinical progression. Advanced quantitative MRI measures such as magnetization transfer, spectroscopy, diffusion imaging, and relaxometry techniques are somewhat more specific and sensitive for underlying pathology. These measures are particularly useful in revealing diffuse damage in cerebral white and gray matter and therefore may help resolve the dissociation between clinical and conventional MRI findings. In this article, we provide an overview of the array of tools available with brain and spinal cord MRI technology as it is applied to MS. We review the most recent data regarding the role of conventional and advanced MRI techniques in the assessment of MS. We focus on the most relevant pathologic and clinical correlation studies relevant to these measures.

brain

diffusion imaging

iron

magnetization transfer

MR spectroscopy

MRI

Multiple sclerosis

spinal cord

Details

Title: Subtitle: MRI in Multiple Sclerosis: What’s Inside the Toolbox?
Creators: Mohit Neema - Brigham and Women's Hospital
James Stankiewicz - Brigham and Women's Hospital
Ashish Arora - Brigham and Women's Hospital
Zachary D. Guss - Brigham and Women's Hospital
Rohit Bakshi - Brigham and Women's Hospital
Resource Type: Journal article
Publication Details: Neurotherapeutics, Vol.4(4), pp.602-617
Publisher: Elsevier Inc
DOI: 10.1016/j.nurt.2007.08.001
PMID: 17920541
PMCID: PMC7479680
ISSN: 1933-7213
eISSN: 1878-7479
Language: English
Date published: 10/01/2007
Academic Unit: Psychiatry
Record Identifier: 9984627306502771

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