Journal article
MRI monitoring of macaque monkeys in neuroscience: Case studies, resource and normative data comparisons
NeuroImage (Orlando, Fla.), Vol.230, pp.117778-117778
04/15/2021
DOI: 10.1016/j.neuroimage.2021.117778
PMID: 33497775
Abstract
Information from Magnetic Resonance Imaging (MRI) is useful for diagnosis and treatment management of human neurological patients. MRI monitoring might also prove useful for non-human animals involved in neuroscience research provided that MRI is available and feasible and that there are no MRI contra-indications precluding scanning. However, MRI monitoring is not established in macaques and a resource is urgently needed that could grow with scientific community contributions. Here we show the utility and potential benefits of MRI-based monitoring in a few diverse cases with macaque monkeys. We also establish a PRIMatE MRI Monitoring (PRIME-MRM) resource within the PRIMatE Data Exchange (PRIME-DE) and quantitatively compare the cases to normative information drawn from MRI data from typical macaques in PRIME-DE. In the cases, the monkeys presented with no or mild/moderate clinical signs, were well otherwise and MRI scanning did not present a significant increase in welfare impact. Therefore, they were identified as suitable candidates for clinical investigation, MRI-based monitoring and treatment. For each case, we show MRI quantification of internal controls in relation to treatment steps and comparisons with normative data in typical monkeys drawn from PRIME-DE. We found that MRI assists in precise and early diagnosis of cerebral events and can be useful for visualising, treating and quantifying treatment response. The scientific community could now grow the PRIME-MRM resource with other cases and larger samples to further assess and increase the evidence base on the benefits of MRI monitoring of primates, complementing the animals’ clinical monitoring and treatment regime.
Details
- Title: Subtitle
- MRI monitoring of macaque monkeys in neuroscience: Case studies, resource and normative data comparisons
- Creators
- Fabien Balezeau - Biosciences Institute, Newcastle University, Newcastle upon Tyne, United KingdomJennifer Nacef - Biosciences Institute, Newcastle University, Newcastle upon Tyne, United KingdomYukiko Kikuchi - Biosciences Institute, Newcastle University, Newcastle upon Tyne, United KingdomFelix Schneider - Biosciences Institute, Newcastle University, Newcastle upon Tyne, United KingdomFrancesca Rocchi - Biosciences Institute, Newcastle University, Newcastle upon Tyne, United KingdomRoss S Muers - Biosciences Institute, Newcastle University, Newcastle upon Tyne, United KingdomRocio Fernandez-Palacios O'Connor - Comparative Biology Centre, Newcastle University, Newcastle upon Tyne, United KingdomChristoph Blau - Comparative Biology Centre, Newcastle University, Newcastle upon Tyne, United KingdomBenjamin Wilson - Biosciences Institute, Newcastle University, Newcastle upon Tyne, United KingdomRichard C Saunders - Laboratory of Neuropsychology, National Institutes of Health (NIMH), Bethesda, MD, United StatesMatthew Howard - Department of Neurosurgery, University of Iowa, Iowa City, IA, United StatesAlexander Thiele - Biosciences Institute, Newcastle University, Newcastle upon Tyne, United KingdomTimothy D Griffiths - Biosciences Institute, Newcastle University, Newcastle upon Tyne, United KingdomChristopher I Petkov - Biosciences Institute, Newcastle University, Newcastle upon Tyne, United KingdomKathy Murphy - Comparative Biology Centre, Newcastle University, Newcastle upon Tyne, United Kingdom
- Resource Type
- Journal article
- Publication Details
- NeuroImage (Orlando, Fla.), Vol.230, pp.117778-117778
- DOI
- 10.1016/j.neuroimage.2021.117778
- PMID
- 33497775
- NLM abbreviation
- Neuroimage
- ISSN
- 1053-8119
- eISSN
- 1095-9572
- Publisher
- Elsevier Inc
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: R01-DC04290, WT091681MA, WT092606AIA, BB/J009849/1, MECHIDENT 724198; DOI: 10.13039/100010269, name: Wellcome Trust, award: R01-DC04290, WT091681MA, WT092606AIA, BB/J009849/1, MECHIDENT 724198; DOI: 10.13039/100016774, name: Centro Internacional de la Papa, award: R01-DC04290, WT091681MA, WT092606AIA, BB/J009849/1, MECHIDENT 724198; DOI: 10.13039/501100000268, name: Biotechnology and Biological Sciences Research Council, award: R01-DC04290, WT091681MA, WT092606AIA, BB/J009849/1, MECHIDENT 724198; DOI: 10.13039/501100000781, name: European Research Council, award: R01-DC04290, WT091681MA, WT092606AIA, BB/J009849/1, MECHIDENT 724198
- Language
- English
- Date published
- 04/15/2021
- Academic Unit
- Neurology; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
- Record Identifier
- 9984070575802771
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