Journal article
MRI reveals hemodynamic changes with acute maternal hyperoxygenation in human fetuses with and without congenital heart disease
Prenatal diagnosis, Vol.36(3), pp.274-281
03/01/2016
DOI: 10.1002/pd.4762
PMID: 26701792
Abstract
ObjectiveWe investigated the physiologic impact of acute maternal hyperoxygenation (MH) in human fetuses with and without congenital heart disease (CHD) using fetal cardiac magnetic resonance (CMR) in order to explore the potential therapeutic benefits of chronic MH.
MethodsWe examined 17 normal and 20 late gestation human fetuses with CHD on a 1.5T CMR system. Flows were measured in major fetal vessels using phase contrast MRI. The T2 of umbilical venous blood was measured using T2 mapping. The measurements were repeated during acute MH. The results were compared using a Student's t-test, with p-value 0.05 considered statistically significant.
ResultsAt baseline, the umbilical venous T2 (oxygen saturation) was lower in CHD fetuses than in normals, with significant increase with MH (p=0.01). Both groups showed significant increase in pulmonary blood flow during MH, which was more dramatic in CHD (p=0.005). There was a reduction in ductus arteriosus flow in CHD during MH (p=0.04). There was no significant difference in blood flow in any of the other major vessels.
ConclusionThis study suggests that fetal MR identifies the expected hemodynamic changes associated with acute MH. MRI could be useful as a method for monitoring the impact of chronic MH in fetuses with CHD. (c) 2015 John Wiley & Sons, Ltd.
Details
- Title: Subtitle
- MRI reveals hemodynamic changes with acute maternal hyperoxygenation in human fetuses with and without congenital heart disease
- Creators
- Prashob Porayette - Hospital for Sick ChildrenSujana Madathil - Hospital for Sick ChildrenLiqun Sun - Hospital for Sick ChildrenEdgar Jaeggi - Hospital for Sick ChildrenLars Grosse-Wortmann - Hospital for Sick ChildrenShi-Joon Yoo - Hospital for Sick ChildrenEdward Hickey - Hospital for Sick ChildrenSteven P. Miller - Hospital for Sick ChildrenChristopher K. Macgowan - Hospital for Sick ChildrenMike Seed - Hospital for Sick Children
- Resource Type
- Journal article
- Publication Details
- Prenatal diagnosis, Vol.36(3), pp.274-281
- Publisher
- Wiley
- DOI
- 10.1002/pd.4762
- PMID
- 26701792
- ISSN
- 0197-3851
- eISSN
- 1097-0223
- Number of pages
- 8
- Language
- English
- Date published
- 03/01/2016
- Academic Unit
- Cardiology; Stead Family Department of Pediatrics; Neurology (Pediatrics); Internal Medicine
- Record Identifier
- 9984353934202771
Metrics
9 Record Views