MRI‐Guided High‐Intensity Focused Ultrasound as an Emerging Therapy for Stroke: A Review

Atif Zafar; Syed A. Quadri; Mudassir Farooqui; Santiago Ortega‐Gutiérrez; Omid R. Hariri; Maryam Zulfiqar; Asad Ikram; Muhammad Adnan Khan; Sajid S. Suriya; Joel R. Nunez‐Gonzalez; Stefan Posse; Martin M. Mortazavi; Howard Yonas

doi:10.1111/jon.12568

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MRI‐Guided High‐Intensity Focused Ultrasound as an Emerging Therapy for Stroke: A Review

Journal article

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MRI‐Guided High‐Intensity Focused Ultrasound as an Emerging Therapy for Stroke: A Review

Atif Zafar, Syed A. Quadri, Mudassir Farooqui, Santiago Ortega‐Gutiérrez, Omid R. Hariri, Maryam Zulfiqar, Asad Ikram, Muhammad Adnan Khan, Sajid S. Suriya, Joel R. Nunez‐Gonzalez, …

Journal of neuroimaging, Vol.29(1), pp.5-13

01/2019

DOI: 10.1111/jon.12568

PMID: 30295987

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Abstract

ABSTRACT Stroke, either ischemic or hemorrhagic, accounts for significantly high morbidity and mortality rates around the globe effecting millions of lives annually. For the past few decades, ultrasound has been extensively investigated to promote clot lysis for the treatment of stroke, myocardial infarction, and acute peripheral arterial occlusions, with or without the use of tPA or contrast agents. In the age of modern minimal invasive techniques, magnetic resonance imaging‐guided high‐intensity focused ultrasound is a new emerging modality that seems to promise therapeutic utilities for both ischemic and hemorrhagic stroke. High‐intensity focused ultrasound causes thermal heating as the tissue absorbs the mechanical energy transmitted by the ultrasonic waves leading to tissue denaturation and coagulation. Several in‐vitro and in‐vivo studies have demonstrated the viability of this technology for sonothrombolysis in both types of stroke and have warranted clinical trials. Apart from safety and efficacy, initiation of trials would further enable answers regarding its practical application in a clinical setup. Though this technology has been under study for treatment of various brain diseases for some decades now, relatively very few neurologists and even neurosurgeons seem to be acquainted with it. The aim of this review is to provide basic understanding of this powerful technology and discuss its clinical application and potential role as an emerging viable therapeutic option for the future management of stroke.

Focused ultrasound

hemorrhage

Insightec

stroke

thermal ablation

Details

Title: Subtitle: MRI‐Guided High‐Intensity Focused Ultrasound as an Emerging Therapy for Stroke: A Review
Creators: Atif Zafar - University of New Mexico Hospital
Syed A. Quadri - University of New Mexico Hospital
Mudassir Farooqui - University of New Mexico Hospital
Santiago Ortega‐Gutiérrez - University of Iowa
Omid R. Hariri - Stanford University
Maryam Zulfiqar - Department of Neurology University of Pittsburgh Medical Center Pittsburgh PA
Asad Ikram - University of New Mexico Hospital
Muhammad Adnan Khan - University of New Mexico Hospital
Sajid S. Suriya - University of New Mexico Hospital
Joel R. Nunez‐Gonzalez - University of New Mexico Hospitals
Stefan Posse - University of New Mexico Hospital
Martin M. Mortazavi - California Institute of Neuroscience Thousand Oaks CA
Howard Yonas - University of New Mexico
Resource Type: Journal article
Publication Details: Journal of neuroimaging, Vol.29(1), pp.5-13
DOI: 10.1111/jon.12568
PMID: 30295987
NLM abbreviation: J Neuroimaging
ISSN: 1051-2284
eISSN: 1552-6569
Number of pages: 9
Language: English
Date published: 01/2019
Academic Unit: Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
Record Identifier: 9984302202402771

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