Journal article
MUTYH Exon 7 and 13 Mutations Associated with Colorectal Cancer (MAP Syndrome) Are Not Commonly Associated with Sporadic Pancreatic Cancer
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], Vol.9(6), pp.793-796
2009
DOI: 10.1159/000199440
PMID: 20110747
Abstract
Background: Biallelic MUTYH exon 7 and 13 mutations are associated with a high frequency of somatic K-ras gene guanine to thymine transversion mutations at codon 12 position 1 in MUTYH-associated polyposis patients who have increased risk of colon cancer. The purpose of this study was to determine if a similar association exists between exon 7 and 13 MUTYH mutations and pancreatic cancer. Methods: Genomic DNA samples from 140 patients with pancreatic cancer and 107 controls were sequenced and analyzed for mutations in each of MUTYH exons 7 and 13. Results: Two patients with pancreatic cancer were identified as heterozygous for a MUTYH Y165C germline mutation. One pancreatic cancer patient was heterozygous for a G382D mutation and an additional patient was heterozygous for a novel missen se mutation, L406M. No biallelic mutations were identified in pancreatic cancer or control subjects. Conclusion: Despite their association with somatic K-ras mutations and an increased risk of colorecta! cancer in MUTYH-associated polyposis patients, MUTYH exon 7 and 13 mutations were not associated with pancreatic cancer in our cohort.
Details
- Title: Subtitle
- MUTYH Exon 7 and 13 Mutations Associated with Colorectal Cancer (MAP Syndrome) Are Not Commonly Associated with Sporadic Pancreatic Cancer
- Creators
- Lauren M Smith - School of Arts and Sciences, University of Pittsburgh, and University of Pittsburgh Cancer institute, Pittsburgh, Pa., USASaima Sharif - Division of Oncology, University of Pittsburgh, and University of Pittsburgh Cancer institute, Pittsburgh, Pa., USARandall Brand - Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, and University of Pittsburgh Cancer institute, Pittsburgh, Pa., USAErin Fink - Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, and University of Pittsburgh Cancer institute, Pittsburgh, Pa., USAJanette Lamb - Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, and University of Pittsburgh Cancer institute, Pittsburgh, Pa., USADavid C Whitcomb - Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, and University of Pittsburgh Cancer institute, Pittsburgh, Pa., USA
- Resource Type
- Journal article
- Publication Details
- Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], Vol.9(6), pp.793-796
- Publisher
- Elsevier B.V
- DOI
- 10.1159/000199440
- PMID
- 20110747
- ISSN
- 1424-3903
- eISSN
- 1424-3911
- Language
- English
- Date published
- 2009
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984094367402771
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