Journal article
MYCOBACTERIUM CHIMAERA INFECTIONS AFTER CARDIOVASCULAR SURGERY: LESSONS FROM A GLOBAL OUTBREAK
Transactions of the American Clinical and Climatological Association, Vol.130, pp.136-144
2019
PMID: 31516177
Abstract
A global outbreak of invasive
Mycobacterium chimaera
infections has been associated with exposure to certain heater-cooler devices (HCDs) used during cardiopulmonary bypass. Outbreak investigations have shown that these HCDs harbor
M. chimaera
in water circuits and generate bio-aerosols in the operating room, leading to airborne transmission to patients during surgery. Whole genome sequencing data support a common-source outbreak originating at an HCD manufacturing facility. Most clinical infections are associated with implanted devices, diagnosis is often delayed, and treatment requires device removal and prolonged antibiotic therapy. Because it is nearly impossible to eradicate
M. chimaera
from HCDs using existing disinfection approaches, strict separation of HCD exhaust from operating room air is necessary to prevent patient exposure. Lessons learned from this outbreak include: 1) medical device risks are difficult to predict, requiring improved expert review before approval, and 2) advances in genomics provide powerful tools for outbreak investigation and public health surveillance.
Details
- Title: Subtitle
- MYCOBACTERIUM CHIMAERA INFECTIONS AFTER CARDIOVASCULAR SURGERY: LESSONS FROM A GLOBAL OUTBREAK
- Creators
- DANIEL J DIEKEMA - IOWA CITY, IOWA
- Resource Type
- Journal article
- Publication Details
- Transactions of the American Clinical and Climatological Association, Vol.130, pp.136-144
- Publisher
- American Clinical and Climatological Association
- PMID
- 31516177
- ISSN
- 0065-7778
- Language
- English
- Date published
- 2019
- Academic Unit
- Infectious Diseases; Pathology; Internal Medicine
- Record Identifier
- 9984001237502771
Metrics
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