Journal article
Macro-optical color assessment of the pulmonary airways with subsequent three-dimensional multidetector-x-ray-computed-tomography assisted display
Journal of Biomedical Optics, Vol.10(5), pp.051703-0517011
10/31/2005
DOI: 10.1117/1.2112767
PMID: 16292955
Abstract
Bronchial diseases alter the color and structural characteristics of the pulmonary mucosa through changes in blood flow, epithelial thickening, and abnormal cell growth. Current analysis of these subtle changes includes visual interpretation of the airway color and topography through bronchoscopy procedures, and quantitative multidetector-x-ray-computed-tomography (MDCT)-based structural analysis, each affording valuable insights to the health of the lungs. The fusion of the bronchoscopy and MDCT image data promises to provide a synergistic data set exhibiting both mucosal color and topography crucial to fostering an understanding of airway structure and function. A real-time airway color analysis imaging system is developed and utilized to perform pulmonary mucosal color assessment in healthy volunteers with subsequent comparative studies performed in example disease states. Our results indicate that macro-optical digital bronchoscopes with appropriate image analysis may have a significant impact on understanding bronchial diseases. To ensure the correct interpretation of scene content, which is critical in the assessment of airway topography, we are developing methods of extracting 3-D structure from 2-D bronchoscope images utilizing MDCT imaging techniques. The resulting 3-D true-color images of the pulmonary mucosa facilitate the combination of mucosal color and topography analysis as well as region of interest localization within the airway tree.
Details
- Title: Subtitle
- Macro-optical color assessment of the pulmonary airways with subsequent three-dimensional multidetector-x-ray-computed-tomography assisted display
- Creators
- Melissa Suter - University of Iowa Hospitals and ClinicsGeoffrey McLennan - University of Iowa Hospitals and ClinicsJoseph M Reinhardt - University of IowaDavid Riker - University of Iowa Hospitals and ClinicsEric A Hoffman - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of Biomedical Optics, Vol.10(5), pp.051703-0517011
- DOI
- 10.1117/1.2112767
- PMID
- 16292955
- ISSN
- 1083-3668
- eISSN
- 1560-2281
- Language
- English
- Date published
- 10/31/2005
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
- Record Identifier
- 9984197145802771
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