Journal article
Macrophage Plasticity and Function in the Eye and Heart
Trends in immunology, Vol.40(9), pp.825-841
09/01/2019
DOI: 10.1016/j.it.2019.07.002
PMID: 31422901
Abstract
Macrophages are important mediators of inflammation and tissue remodeling. Recent insights into the heterogeneity of macrophage subpopulations have renewed interest in their functional diversity in homeostasis and disease. In addition, their plasticity enables them to perform a variety of functions in response to changing tissue contexts, such as those imposed by aging. These qualities make macrophages particularly intriguing cells given their dichotomous role in protecting against, or accelerating, diseases of the cardiovascular system and the eye, two tissues that are particularly susceptible to the effects of aging. We review novel perspectives on macrophage biology, as informed by recent studies detailing the diversity of macrophage identity and function, as well as mechanisms influencing macrophage behavior that might offer opportunities for new therapeutic strategies.
Details
- Title: Subtitle
- Macrophage Plasticity and Function in the Eye and Heart
- Creators
- Zelun Wang - Washington University in St. LouisAndrew L Koenig - Washington University in St. LouisKory J Lavine - Washington University in St. LouisRajendra S Apte - Washington University in St. Louis
- Resource Type
- Journal article
- Publication Details
- Trends in immunology, Vol.40(9), pp.825-841
- DOI
- 10.1016/j.it.2019.07.002
- PMID
- 31422901
- ISSN
- 1471-4906
- eISSN
- 1471-4981
- Grant note
- T32 EY013360 / NEI NIH HHS P30 EY002687 / NEI NIH HHS R01 HL139714 / NHLBI NIH HHS R21 EY026707 / NEI NIH HHS R01 EY019287 / NEI NIH HHS T32 HL134635 / NHLBI NIH HHS K08 HL123519 / NHLBI NIH HHS P30 DK056341 / NIDDK NIH HHS R01 HL138466 / NHLBI NIH HHS
- Language
- English
- Date published
- 09/01/2019
- Academic Unit
- Stead Family Department of Pediatrics
- Record Identifier
- 9985161354802771
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