Journal article
Macrophages in Neovascular Age-Related Macular Degeneration: Friends or Foes?
Eye (London), Vol.23(4), pp.747-755
04/2009
DOI: 10.1038/eye.2008.206
PMID: 18600240
Abstract
The events that lead to choroidal neovascularization in eyes with age-related macular degeneration are poorly understood. One possibility that has been explored in a number of studies is that macrophages can promote neovascular changes. In this manuscript we summarize the evidence for inflammation in general and macrophages in particular in pathologic neovascularization, and discuss how the diverse functions of these cells may promote or inhibit macular disease. We also discuss some of the conflicting findings regarding the role of macrophages in experimental choroidal neovascularization in mouse models, and suggest areas for future research.
Details
- Title: Subtitle
- Macrophages in Neovascular Age-Related Macular Degeneration: Friends or Foes?
- Creators
- Jessica M Skeie - University of IowaRobert F Mullins - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Eye (London), Vol.23(4), pp.747-755
- DOI
- 10.1038/eye.2008.206
- PMID
- 18600240
- ISSN
- 0950-222X
- eISSN
- 1476-5454
- Language
- English
- Date published
- 04/2009
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9984182756502771
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