Macroscopic Stiffness of Breast Tumors Predicts Metastasis

Joseph Fenner; Amanda C. Stacer; Frank Winterroth; Timothy D. Johnson; Kathryn E. Luker; Gary D. Luker

doi:10.1038/srep05512

Back

Macroscopic Stiffness of Breast Tumors Predicts Metastasis

Journal article

Open access

Peer reviewed

Macroscopic Stiffness of Breast Tumors Predicts Metastasis

Joseph Fenner, Amanda C. Stacer, Frank Winterroth, Timothy D. Johnson, Kathryn E. Luker and Gary D. Luker

Scientific reports, Vol.4(1), pp.5512-5512

07/01/2014

DOI: 10.1038/srep05512

PMCID: PMC4076689

PMID: 24981707

Files and links (1)

url

https://doi.org/10.1038/srep05512View

Published (Version of record) Open Access

Abstract

Mechanical properties of tumors differ substantially from normal cells and tissues. Changes in stiffness or elasticity regulate pro-metastatic behaviors of cancer cells, but effects have been documented predominantly in isolated cells or in vitro cell culture systems. To directly link relative stiffness of tumors to cancer progression, we combined a mouse model of metastatic breast cancer with ex vivo measurements of bulk moduli of freshly excised, intact tumors. We found a high, inverse correlation between bulk modulus of resected tumors and subsequent local recurrence and metastasis. More compliant tumors were associated with more frequent, larger local recurrences and more extensive metastases than mice with relatively stiff tumors. We found that collagen content of resected tumors correlated with bulk modulus values. These data establish that relative differences in tumor stiffness correspond with tumor progression and metastasis, supporting further testing and development of tumor compliance as a prognostic biomarker in breast cancer.

Multidisciplinary Sciences

Science & Technology

Science & Technology - Other Topics

Details

Title: Subtitle: Macroscopic Stiffness of Breast Tumors Predicts Metastasis
Creators: Joseph Fenner - University of Michigan–Ann Arbor
Amanda C. Stacer - University of Michigan–Ann Arbor
Frank Winterroth - University of Michigan–Ann Arbor
Timothy D. Johnson - University of Michigan–Ann Arbor
Kathryn E. Luker - Univ Michigan Med Sch, Coll Engn, Ann Arbor, MI 48109 USA
Gary D. Luker - University of Michigan–Ann Arbor
Resource Type: Journal article
Publication Details: Scientific reports, Vol.4(1), pp.5512-5512
Publisher: NATURE PORTFOLIO
DOI: 10.1038/srep05512
PMID: 24981707
PMCID: PMC4076689
ISSN: 2045-2322
eISSN: 2045-2322
Number of pages: 8
Grant note: R01CA170198; R01CA136553; R01CA142750; P50CA093990 / United States Institute of Health
Language: English
Date published: 07/01/2014
Academic Unit: Obstetrics and Gynecology
Record Identifier: 9984696761002771

Metrics

3 Record Views

128 Times Cited - Web of Science

See more details