Journal article
Macular Pigment and Lutein Supplementation in Choroideremia
Experimental Eye Research, Vol.74(3), pp.371-381
03/2002
DOI: 10.1006/exer.2001.1126
PMID: 12014918
Abstract
Choroideremia is an incurable X-linked retinal degeneration caused by mutations in the gene encoding Rab escort protein-1. A group of clinically defined and genotyped patients were studied to determine: (1) the degree of rod and cone dysfunction and structural abnormality in the central retina and the level of macular pigment; and (2) the response of macular pigment and foveal vision to a 6month trial of supplementation with oral lutein (at 20mg per day). Rod and cone-mediated function was measured with dark-adapted static perimetry; in vivo retinal structure was determined with optical coherence tomography; and macular pigment optical density was measured with heterochromatic flicker photometry. In this cohort of patients (ages 15–65 years), both rod- and cone-mediated central function declined with age as did central retinal thickness. Macular pigment levels did not differ between patients and male control subjects. Supplementation of oral lutein in a subset of patients led to an increase in serum lutein and macular pigment levels; absolute foveal sensitivity did not change. It is concluded that macular pigment density can be augmented by oral intake of lutein in patients with choroideremia. There was no short-term change in the central vision of the patients on the supplement, but long-term influences of lutein supplementation on disease natural history warrant further study.
Details
- Title: Subtitle
- Macular Pigment and Lutein Supplementation in Choroideremia
- Creators
- Jacque L Duncan - Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, U.S.ATomas S Aleman - Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, U.S.ALeigh M Gardner - Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, U.S.AElaine De Castro - Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, U.S.ADaniel A Marks - Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, U.S.AJessica M Emmons - Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, U.S.AMichelle L Bieber - Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, U.S.AJanet D Steinberg - Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, U.S.AJean Bennett - Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, U.S.AEdwin M Stone - Department of Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City, IA, U.S.AIan M MacDonald - Department of Ophthalmology, University of Alberta, Edmonton, Alberta, CanadaArtur V Cideciyan - Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, U.S.AMaureen G Maguire - Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, U.S.ASamuel G Jacobson - Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, U.S.A
- Resource Type
- Journal article
- Publication Details
- Experimental Eye Research, Vol.74(3), pp.371-381
- DOI
- 10.1006/exer.2001.1126
- PMID
- 12014918
- NLM abbreviation
- Exp Eye Res
- ISSN
- 0014-4835
- eISSN
- 1096-0007
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 03/2002
- Academic Unit
- Iowa Neuroscience Institute; Ophthalmology and Visual Sciences
- Record Identifier
- 9983980396502771
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