Macular Vascular Abnormalities Identified by Optical Coherence Tomographic Angiography in Patients With Sickle Cell Disease

Ian C Han; Mongkol Tadarati; Adrienne W Scott

doi:10.1001/jamaophthalmol.2015.2824

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Macular Vascular Abnormalities Identified by Optical Coherence Tomographic Angiography in Patients With Sickle Cell Disease

Journal article

Open access

Peer reviewed

Macular Vascular Abnormalities Identified by Optical Coherence Tomographic Angiography in Patients With Sickle Cell Disease

Ian C Han, Mongkol Tadarati and Adrienne W Scott

JAMA ophthalmology, Vol.133(11), pp.1337-1340

11/2015

DOI: 10.1001/jamaophthalmol.2015.2824

PMID: 26313686

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Abstract

Patients with sickle cell disease may develop various macular vascular abnormalities that have not been described previously and can be seen using optical coherence tomographic angiography. Ten eyes from 5 consecutive patients (3 men and 2 women) with sickle cell disease (4 patients with hemoglobin SS disease and 1 patient with hemoglobin SC disease) were included. The mean age was 37.6 years. Five of 10 eyes (50%) had retinal thinning that was identified using spectral-domain optical coherence tomography. Each of these eyes had corresponding loss of vascular density in the superficial or deep retinal plexus (or both). Optical coherence tomographic angiography provides a novel way to view the retinal vasculature, including the superficial and deep capillary plexus, and may provide a sensitive method for identifying macular vascular abnormalities in patients with sickle cell disease.

Retinal Vessels - pathology

Retinal Diseases - diagnosis

Prospective Studies

Tomography, Optical Coherence

Humans

Organ Size

Adult

Female

Male

Anemia, Sickle Cell - diagnosis

Retina - pathology

Fluorescein Angiography

Details

Title: Subtitle: Macular Vascular Abnormalities Identified by Optical Coherence Tomographic Angiography in Patients With Sickle Cell Disease
Creators: Ian C Han - Retina Division, Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, Maryland
Mongkol Tadarati - Retina Division, Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, Maryland2Retina Division, Department of Ophthalmology, Rajavithi Hospital, College of Medicine, Rangsit University, Bangkok, Thailand
Adrienne W Scott - Retina Division, Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, Maryland
Resource Type: Journal article
Publication Details: JAMA ophthalmology, Vol.133(11), pp.1337-1340
DOI: 10.1001/jamaophthalmol.2015.2824
PMID: 26313686
NLM abbreviation: JAMA Ophthalmol
ISSN: 2168-6165
eISSN: 2168-6173
Publisher: United States
Language: English
Date published: 11/2015
Academic Unit: Ophthalmology and Visual Sciences
Record Identifier: 9983980083102771

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