Journal article
Macular function in macular degenerations: repeatability of microperimetry as a potential outcome measure for ABCA4-associated retinopathy trials
Investigative ophthalmology & visual science, Vol.53(2), pp.841-852
02/2012
DOI: 10.1167/iovs.11-8415
PMCID: PMC3317423
PMID: 22247458
Abstract
To measure macular visual function in patients with unstable fixation, to define the photoreceptor source of this function, and to estimate its test-retest repeatability as a prerequisite to clinical trials. Patients (n = 38) with ABCA4-associated retinal degeneration (RD) or with retinitis pigmentosa (RP) were studied with retina-tracking microperimetry along the foveo-papillary profile between the fovea and the optic nerve head, and point-by-point test-retest repeatability was estimated. A subset with foveal fixation was also studied with dark-adapted projection perimetry using monochromatic blue and red stimuli along the horizontal meridian. Macular function in ABCA4-RD patients transitioned from lower sensitivity at the parafovea to higher sensitivity in the perifovea. RP patients had the inverse pattern. Red-on-red microperimetric sensitivities successfully avoided ceiling effects and were highly correlated with absolute sensitivities. Point-by-point test-retest limits (95% confidence intervals) were ±4.2 dB; repeatability was not related to mean sensitivity, eccentricity from the fovea, age, fixation location, or instability. Repeatability was also not related to the local slope of sensitivity and was unchanged in the parapapillary retina. Microperimetry allows reliable testing of macular function in RD patients without foveal fixation in longitudinal studies evaluating natural disease progression or efficacy of therapeutic trials. A single estimate of test-retest repeatability can be used to determine significant changes in visual function at individual retinal loci within diseased regions that are homogeneous and those that are heterogeneous and also in transition zones at high risk for disease progression.
Details
- Title: Subtitle
- Macular function in macular degenerations: repeatability of microperimetry as a potential outcome measure for ABCA4-associated retinopathy trials
- Creators
- Artur V Cideciyan - Scheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. cideciya@mail.med.upenn.eduMalgorzata SwiderTomas S AlemanWillam J FeuerSharon B SchwartzRobert C RussellJanet D SteinbergEdwin M StoneSamuel G Jacobson
- Resource Type
- Journal article
- Publication Details
- Investigative ophthalmology & visual science, Vol.53(2), pp.841-852
- Publisher
- United States
- DOI
- 10.1167/iovs.11-8415
- PMID
- 22247458
- PMCID
- PMC3317423
- ISSN
- 0146-0404
- eISSN
- 1552-5783
- Grant note
- R01 EY013203 / NEI NIH HHS EY 013203 / NEI NIH HHS
- Language
- English
- Date published
- 02/2012
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9983979981002771
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