Journal article
Macular patterns of neuronal and visual field loss in recovered optic neuritis identified by machine learning
Scientific reports, Vol.14(1), 30935
12/28/2024
DOI: 10.1038/s41598-024-81835-8
PMCID: PMC11680678
PMID: 39730673
Abstract
We used machine learning to investigate the residual visual field (VF) deficits and macula retinal ganglion cell (RGC) thickness loss patterns in recovered optic neuritis (ON). We applied archetypal analysis (AA) to 377 same-day pairings of 10-2 VF and optical coherence tomography (OCT) macula images from 93 ON eyes and 70 normal fellow eyes ≥ 90 days after acute ON. We correlated archetype (AT) weights (total weight = 100%) of VFs and total retinal thickness (TRT), inner retinal thickness (IRT), and macular ganglion cell-inner plexiform layer (GCIPL) thickness. AA showed most ON eyes had a 10-2 VF pattern like the normal fellow eye VF, despite having markedly thinner GCIPL patterns. AA identified 7 VF and 11 retinal thickness ATs for each OCT model. The normal VF AT constituted 80% of ON eyes and 90% of normal fellow eyes. The most common GCIPL AT consisted of diffuse thinning. We identified significant correlations for the normal AT weights using OCT AT weights of five GCIPL ATs (r = 0.45), four TRT ATs (0.53) and two IRT ATs (0.42). Following acute ON, most eyes had complete 10-2 VF recovery despite significant GCIPL thinning, suggesting compensatory mechanisms for vision.
Details
- Title: Subtitle
- Macular patterns of neuronal and visual field loss in recovered optic neuritis identified by machine learning
- Creators
- David Szanto - Icahn School of Medicine at Mount SinaiJui-Kai Wang - University of IowaBrian Woods - Cork University HospitalTobias Elze - Harvard UniversityMona K Garvin - Iowa City VA Health Care SystemLouis R Pasquale - Icahn School of Medicine at Mount SinaiRandy H Kardon - Iowa City VA Health Care SystemJoseph Branco - New York Medical CollegeMark J Kupersmith - Icahn School of Medicine at Mount Sinai
- Resource Type
- Journal article
- Publication Details
- Scientific reports, Vol.14(1), 30935
- DOI
- 10.1038/s41598-024-81835-8
- PMID
- 39730673
- PMCID
- PMC11680678
- NLM abbreviation
- Sci Rep
- ISSN
- 2045-2322
- eISSN
- 2045-2322
- Publisher
- NATURE PORTFOLIO
- Grant note
- NEI R01 EY015473 / Research to Prevent Blindness, Inc., New York, NY unrestricted grant to the Department of Ophthalmology I50 RX003002; VA RR&D I01RX003797 / Department of Veteran Affairs (VA) Center for the Prevention and Treatment of Visual Loss, Rehabilitation Research and Development (RR&D) NEI EY032522 / The New York Eye and Ear Infirmary Foundation, New York, N.Y
- Language
- English
- Date published
- 12/28/2024
- Academic Unit
- Electrical and Computer Engineering; Iowa Neuroscience Institute; Ophthalmology and Visual Sciences
- Record Identifier
- 9984759116202771
Metrics
5 Record Views