Macular pigment density and age-related maculopathy in the Carotenoids in Age-Related Eye Disease Study. An ancillary study of the women's health initiative

Tara L LaRowe; Julie A Mares; D Max Snodderly; Michael L Klein; Billy R Wooten; Richard Chappell; CAREDS Macular Pigment Study Group

doi:10.1016/j.ophtha.2007.06.015

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Macular pigment density and age-related maculopathy in the Carotenoids in Age-Related Eye Disease Study. An ancillary study of the women's health initiative

Journal article

Peer reviewed

Macular pigment density and age-related maculopathy in the Carotenoids in Age-Related Eye Disease Study. An ancillary study of the women's health initiative

Tara L LaRowe, Julie A Mares, D Max Snodderly, Michael L Klein, Billy R Wooten, Richard Chappell and CAREDS Macular Pigment Study Group

Ophthalmology (Rochester, Minn.), Vol.115(5), pp.876-e1

05/2008

DOI: 10.1016/j.ophtha.2007.06.015

PMID: 17868874

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Abstract

To examine the association between intermediate age-related macular degeneration (AMD) and the optical density of macular pigment (MPOD), which is composed of lutein and zeaxanthin from the diet. Cross-sectional cohort study. We included 1698 of 2005 women ages 54 to 86 years and participating in the Carotenoids in Age-Related Eye Disease Study, an ancillary study of the Women's Health Initiative. The MPOD was measured noninvasively by heterochromatic flicker photometry. Fundus photographs were taken to document prevalent AMD. Intermediate AMD (n = 305) and two subtypes-large drusen (n = 233) and pigmentary abnormalities (n = 157). After adjusting for covariates, the odds ratio (OR) and 95% confidence interval (CI) for AMD among women in quintile (Q) 5 (n = 339) versus 1 (n = 340) for MPOD was 1.4 (0.9, 2.1). However, after excluding women with possible unstable diets and recent supplement use due to chronic disease history, associations reversed (OR Q2-5 vs. 1, 0.8; 95% CI, 0.5-1.2), but remained nonsignificant. Associations also differed between middle-aged (54-69 years) and older (> or =70 years) women (P-interaction = 0.09), but less so, after excluding women who were likely to have unstable diets: adjusted ORs (95% CI) were 0.5 (0.3-1.0; P = 0.08) for intermediate AMD among middle-aged women (n = 516) with MPOD in Q2 to Q5 versus 1 and 1.0 (0.5-2.0; P = 0.90) for older women (n = 422). The MPOD is not cross-sectionally associated with AMD. The inconsistency of relationships across age groups and in subgroups of women who are likely to have more stable diets suggests that cross-sectional associations may be biased and highlights the need to study these relationships prospectively.

Macula Lutea - metabolism

Retinal Pigments - metabolism

Xanthophylls - administration & dosage

Women's Health

Cross-Sectional Studies

Bias

Humans

Middle Aged

Risk Factors

Zeaxanthins

Macular Degeneration - metabolism

Diet

Lutein - administration & dosage

Aged, 80 and over

Postmenopause

Female

Surveys and Questionnaires

Aged

Odds Ratio

Photometry

Details

Title: Subtitle: Macular pigment density and age-related maculopathy in the Carotenoids in Age-Related Eye Disease Study. An ancillary study of the women's health initiative
Creators: Tara L LaRowe - Department of Family Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA
Julie A Mares
D Max Snodderly
Michael L Klein
Billy R Wooten
Richard Chappell
CAREDS Macular Pigment Study Group
Resource Type: Journal article
Publication Details: Ophthalmology (Rochester, Minn.), Vol.115(5), pp.876-e1
Publisher: United States
DOI: 10.1016/j.ophtha.2007.06.015
PMID: 17868874
ISSN: 0161-6420
eISSN: 1549-4713
Grant note: DK07665 / NIDDK NIH HHS EY 13018 / NEI NIH HHS R01 EY021532 / NEI NIH HHS
Language: English
Date published: 05/2008
Academic Unit: Ophthalmology and Visual Sciences
Record Identifier: 9983979922002771

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