Journal article
Magnesium as an adjuvant for caudal analgesia in children
Pediatric anesthesia, Vol.24(12), pp.1231-1238
12/01/2014
DOI: 10.1111/pan.12559
PMID: 25315126
Abstract
Background There is a need for an adjuvant agent of caudal block that prolongs its duration and improves the analgesic efficacy to fasten functional recovery. Magnesium is an N-methyl-D-aspartate receptor antagonist that functions as an analgesic. This study was aimed to evaluate whether magnesium as an adjuvant for caudal block in children can improve postoperative analgesia and functional recovery.
Methods Eighty children, 2-6years of age, undergoing inguinal herniorrhaphy, were included in this prospective, randomized, double-blinded study. For caudal block, Group R received ropivacaine 1.5mg center dot ml(-1), 1ml center dot kg(-1) and Group RM received the same dose of ropivacaine mixed with 50mg of magnesium. The Parents' Postoperative Pain Measure (PPPM) score, analgesic consumption, functional recovery, and adverse effects were evaluated at 6, 24, 48, and 72h after surgery, as well as daily thereafter until the child showed full functional recovery.
Results The PPPM score after hospital discharge was significantly lower for Group RM than for Group R at all times (P<0.05). Children in Group RM required less fentanyl for rescue analgesia in the recovery area (16.2% vs 39.5%, P=0.034) and less oral analgesics after discharge (20.5% vs 52.6%, P=0.007). The time to return of normal functional activity was shorter in Group RM (P<0.05). The incidence of adverse effects did not differ between groups.
Conclusions As an adjuvant for caudal analgesia, 50mg magnesium provided superior quality of analgesia and faster return of normal functional activity than local anesthetic alone in children.
Details
- Title: Subtitle
- Magnesium as an adjuvant for caudal analgesia in children
- Creators
- Eun Mi Kim - Hallym UniversityMin-Soo Kim - Yonsei UniversitySeok-Joo Han - Yonsei UniversityBong Ki Moon - Ajou UniversityEun Mi Choi - Hallym UniversityEun Ho Kim - Yonsei UniversityJeong-Rim Lee - Yonsei University
- Resource Type
- Journal article
- Publication Details
- Pediatric anesthesia, Vol.24(12), pp.1231-1238
- DOI
- 10.1111/pan.12559
- PMID
- 25315126
- NLM abbreviation
- Paediatr Anaesth
- ISSN
- 1155-5645
- eISSN
- 1460-9592
- Publisher
- Wiley
- Number of pages
- 8
- Language
- English
- Date published
- 12/01/2014
- Academic Unit
- Anesthesia
- Record Identifier
- 9984806504402771
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