Journal article
Magnesium reduces free radical concentration and preserves left ventricular function after direct current shocks
Resuscitation, Vol.56(2), pp.199-206
2003
DOI: 10.1016/S0300-9572(02)00353-2
PMID: 12589995
Abstract
Objective: Our objective was to determine if magnesium reduces free radicals generated by direct current countershock and preserves left ventricular contractile function. Background: We have previously shown that magnesium reduces free radicals in a coronary occlusion-reperfusion model, and therefore also might reduce free radical generation by direct current shocks. Methods: In eight swine weighing 18–27 kg (mean: 22 kg), using electron paramagnetic resonance, we monitored continuously the coronary sinus concentration of ascorbate free radical, a measure of free radical generation (total oxidative flux). Epicardial shocks (30 J) using a truncated exponential biphasic waveform (5/5 ms) were administered. Each animal received two shocks, one without and one with magnesium, 80 mg/min IV, beginning 10 min before the shock and continuing to 15 min after the shock. Percent fractional area shortening of the left ventricular cavity was determined by 2-dimensional echocardiography. Results: Magnesium shocks resulted in a significantly lower increase in the ascorbate free radical concentration (0.6±4.6%) than no-magnesium shocks (16±3.3%, P<0.05) at 12 min after the shock. Total radical flux was reduced 72% (P<0.05), and left ventricular fractional area shortening was preserved: baseline: 69±2.6%, no-magnesium shocks: 41±2.8% (P<0.05, versus baseline) and magnesium shocks 61±3.7%. Conclusions: Magnesium pre-treatment reduced oxygen free radicals generated by direct current shocks; post-shock left ventricular contractile function was not impaired. Magnesium may be cardioprotective during epicardial (‘surgical’) defibrillation.
Details
- Title: Subtitle
- Magnesium reduces free radical concentration and preserves left ventricular function after direct current shocks
- Creators
- Yi Zhang - Department of Internal Medicine, The Cardiovascular Center, College of Medicine, University of Iowa Hospital, 200 Hawkins Drive, Iowa City, IA 52242, United StatesLoyd R DAVIES - Department of Internal Medicine, The Cardiovascular Center, College of Medicine, University of Iowa Hospital, 200 Hawkins Drive, Iowa City, IA 52242, United StatesSean M MARTIN - Department of Internal Medicine, The Cardiovascular Center, College of Medicine, University of Iowa Hospital, 200 Hawkins Drive, Iowa City, IA 52242, United StatesImran M BAWANEY - Department of Internal Medicine, The Cardiovascular Center, College of Medicine, University of Iowa Hospital, 200 Hawkins Drive, Iowa City, IA 52242, United StatesGarry R BUETTNER - Department of Internal Medicine, The Cardiovascular Center, College of Medicine, University of Iowa Hospital, 200 Hawkins Drive, Iowa City, IA 52242, United StatesRichard E KERBER - Department of Internal Medicine, The Cardiovascular Center, College of Medicine, University of Iowa Hospital, 200 Hawkins Drive, Iowa City, IA 52242, United States
- Resource Type
- Journal article
- Publication Details
- Resuscitation, Vol.56(2), pp.199-206
- Publisher
- Elsevier; Shannon
- DOI
- 10.1016/S0300-9572(02)00353-2
- PMID
- 12589995
- ISSN
- 0300-9572
- eISSN
- 1873-1570
- Language
- English
- Date published
- 2003
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984047756702771
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