Magnetic Resonance Imaging-Defined Osteoarthritis Features and Anterior Knee Pain in Individuals With, or at Risk for, Knee Osteoarthritis: A Multicenter Study on Osteoarthritis

Erin M Macri; Tuhina Neogi; Mohamed Jarraya; Ali Guermazi; Frank Roemer; Cora E Lewis; James C Torner; John A Lynch; Irina Tolstykh; S Reza Jafarzadeh; Joshua J Stefanik

doi:10.1002/acr.24604

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Magnetic Resonance Imaging-Defined Osteoarthritis Features and Anterior Knee Pain in Individuals With, or at Risk for, Knee Osteoarthritis: A Multicenter Study on Osteoarthritis

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Magnetic Resonance Imaging-Defined Osteoarthritis Features and Anterior Knee Pain in Individuals With, or at Risk for, Knee Osteoarthritis: A Multicenter Study on Osteoarthritis

Erin M Macri, Tuhina Neogi, Mohamed Jarraya, Ali Guermazi, Frank Roemer, Cora E Lewis, James C Torner, John A Lynch, Irina Tolstykh, S Reza Jafarzadeh, …

Arthritis care & research (2010), Vol.74(9), pp.1533-1540

03/25/2021

DOI: 10.1002/acr.24604

PMCID: PMC8463633

PMID: 33768706

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Abstract

The lack of strong association between knee osteoarthritis (OA) structural features and pain continues to perplex researchers and clinicians. Evaluating the patellofemoral joint in addition to the tibiofemoral joint alone has contributed to explaining this structure-pain discordance, hence justifying a more comprehensive evaluation of whole-knee OA and pain. The present study, therefore, was undertaken to evaluate the association between patellofemoral and tibiofemoral OA features with localized anterior knee pain (AKP) using 2 study designs. Using cross-sectional data from the Multicenter Osteoarthritis Study, our first approach was a within-person, knee-matched design in which we identified participants with unilateral AKP. We then assessed magnetic resonance imaging (MRI)-derived OA features (cartilage damage, bone marrow lesions [BMLs], osteophytes, and inflammation) in both knees and evaluated the association of patellofemoral and tibiofemoral OA features to unilateral AKP. In our second approach, MRIs from 1 knee per person were scored, and we evaluated the association of OA features to AKP in participants with AKP and participants with no frequent knee pain. Using the first approach (n = 71, 66% women, mean ± SD age 69 ± 8 years), lateral patellofemoral osteophytes (odds ratio [OR] 5.0 [95% confidence interval (95% CI) 1.7-14.6]), whole-knee joint effusion-synovitis (OR 4.7 [95% CI 1.3-16.2]), and infrapatellar synovitis (OR 2.8 [95% CI 1.0-7.8]) were associated with AKP. Using the second approach (n = 882, 59% women, mean ± SD age 69 ± 7 years), lateral and medial patellofemoral cartilage damage (prevalence ratio [PR] 2.3 [95% CI 1.3-4.0] and PR 1.9 [95% CI 1.1-3.3], respectively) and lateral patellofemoral BMLs (PR 2.6 [95% CI 1.5-4.7]) were associated with AKP. Patellofemoral but not tibiofemoral joint OA features and inflammation were associated with AKP.

Details

Title: Subtitle: Magnetic Resonance Imaging-Defined Osteoarthritis Features and Anterior Knee Pain in Individuals With, or at Risk for, Knee Osteoarthritis: A Multicenter Study on Osteoarthritis
Creators: Erin M Macri - Erasmus MC, Rotterdam, The Netherlands, and University of Delaware, Newark
Tuhina Neogi - Boston University School of Medicine
Mohamed Jarraya - Boston University School of Medicine
Ali Guermazi - Boston University School of Medicine
Frank Roemer - Boston University, Boston, Massachusetts, and Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
Cora E Lewis - University of Alabama at Birmingham
James C Torner - University of Iowa, Epidemiology
John A Lynch - University of California San Francisco Medical Center
Irina Tolstykh - University of California, San Francisco
S Reza Jafarzadeh - Boston University and Boston Imaging Core Lab, Boston, Massachusetts
Joshua J Stefanik - Northeastern University
Resource Type: Journal article
Publication Details: Arthritis care & research (2010), Vol.74(9), pp.1533-1540
DOI: 10.1002/acr.24604
PMID: 33768706
PMCID: PMC8463633
NLM abbreviation: Arthritis Care Res (Hoboken)
ISSN: 2151-464X
eISSN: 2151-4658
Grant note: U01 AG018947 / NIA NIH HHS U01 AG018832 / NIA NIH HHS P30 AR072571 / NIAMS NIH HHS U01-AG-19069 / NIH HHS U01 AG019069 / NIA NIH HHS R01-AR-062506 / NIH HHS U01-AG-18820 / NIH HHS U01-AG-18947 / NIH HHS P60 AR047785 / NIAMS NIH HHS P30-AR072571 / NIH HHS K24-AR-070892 / NIH HHS K23 AR070913 / NIAMS NIH HHS U01-AG-18832 / NIH HHS K24 AR070892 / NIAMS NIH HHS P60-AR-047785 / NIH HHS U54-GM-104941 / NIGMS NIH HHS AR-47785 / NIH HHS Banting Postdoctoral Fellowship / CIHR U54 GM104941 / NIGMS NIH HHS R01 AG066010 / NIH HHS R01 AR062506 / NIAMS NIH HHS U01 AG018820 / NIA NIH HHS K23-AR-070913 / NIGMS NIH HHS
Language: English
Date published: 03/25/2021
Academic Unit: Neurology; Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
Record Identifier: 9984214830502771

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