Journal article
Magnetic field activated lipid–polymer hybrid nanoparticles for stimuli-responsive drug release
Acta biomaterialia, Vol.9(3), pp.5447-5452
03/2013
DOI: 10.1016/j.actbio.2012.11.006
PMCID: PMC4077216
PMID: 23149252
Abstract
Stimuli-responsive nanoparticles (SRNPs) offer the potential of enhancing the therapeutic efficacy and minimizing the side-effects of chemotherapeutics by controllably releasing the encapsulated drug at the target site. Currently controlled drug release through external activation remains a major challenge during the delivery of therapeutic agents. Here we report a lipid–polymer hybrid nanoparticle system containing magnetic beads for stimuli-responsive drug release using a remote radio frequency (RF) magnetic field. These hybrid nanoparticles show long-term stability in terms of particle size and polydispersity index in phosphate-buffered saline (PBS). Controllable loading of camptothecin (CPT) and Fe
3
O
4
in the hybrid nanoparticles was demonstrated. RF-controlled drug release from these nanoparticles was observed. In addition, cellular uptake of the SRNPs into MT2 mouse breast cancer cells was examined. Using CPT as a model anticancer drug the nanoparticles showed a significant reduction in MT2 mouse breast cancer cell growth
in vitro
in the presence of a remote RF field. The ease of preparation, stability, and controllable drug release are the strengths of the platform and provide the opportunity to improve cancer chemotherapy.
Details
- Title: Subtitle
- Magnetic field activated lipid–polymer hybrid nanoparticles for stimuli-responsive drug release
- Creators
- Seong Deok Kong - Materials Science and Engineering, University of California San Diego, La Jolla, CA 92093, USAMarta Sartor - Materials Science and Engineering, University of California San Diego, La Jolla, CA 92093, USAChe-Ming Jack Hu - Department of Nanoengineering, University of California San Diego, La Jolla, CA 92093, USAWeizhou Zhang - Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla, CA 92093, USALiangfang Zhang - Department of Nanoengineering, University of California San Diego, La Jolla, CA 92093, USASungho Jin - Materials Science and Engineering, University of California San Diego, La Jolla, CA 92093, USA
- Resource Type
- Journal article
- Publication Details
- Acta biomaterialia, Vol.9(3), pp.5447-5452
- DOI
- 10.1016/j.actbio.2012.11.006
- PMID
- 23149252
- PMCID
- PMC4077216
- NLM abbreviation
- Acta Biomater
- ISSN
- 1742-7061
- eISSN
- 1878-7568
- Grant note
- DOI: 10.13039/100007911, name: University of California San Diego, award: DMR-1006081; name: NSF, award: CMMI-1031239
- Language
- English
- Date published
- 03/2013
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984083285002771
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