Journal article
Magnetic resonance and computed tomography imaging features of epithelioid sarcoma in children and young adults with pathological and clinical correlation: a report from Children's Oncology Group study ARST0332
Pediatric radiology, Vol.49(7), pp.922-932
06/2019
DOI: 10.1007/s00247-019-04389-2
PMCID: PMC6576270
PMID: 30929036
Abstract
To correlate imaging features of epithelioid sarcoma in children and young adults enrolled in Children's Oncology Group study ARST0332 with clinical and pathological findings.
Fifteen patients (6 males; median age 16.1 years, range 6.5-24.8 years) with epithelioid sarcoma enrolled in ARST0332 had preoperative imaging (MRI, n=10; CT, n=5) that was reviewed by two radiologists who recorded numerous features including presence and percentage of tumor necrosis, presence of surrounding edema, and lymph node involvement. Discrepancies between reviewers were adjudicated by concurrent re-review. We correlated imaging findings with histological assessment of percentage tumor necrosis, proximal- vs. classic-type histology, lymph node involvement and recurrence.
Eleven patients (11/15, 73%) had proximal-type histology tumors. Ten of 14 tumors (71%) had imaging evidence of necrosis. Among the nine tumors with imaging and histological estimates of percentage necrosis, agreement was within 30% (in six tumors there was ≤10% difference between pathology and imaging). All 10 tumors imaged with MRI had surrounding edema. Four patients had biopsy-proven nodal involvement; all had necrotic nodes on imaging. There were four false-positives for nodal involvment by imaging. Twelve patients (12/15, 80%) had recurrences (local only, n=1; local and distant, n=1; distant only, n=10).
Proximal-type histology was prevalent in this young cohort with preoperative imaging. Necrosis is common in primary tumors and involved nodes. There is good agreement between histological and imaging estimates of primary tumor necrosis. Surrounding tumor edema is common in this tumor, which is known to spread along fascial planes.
Details
- Title: Subtitle
- Magnetic resonance and computed tomography imaging features of epithelioid sarcoma in children and young adults with pathological and clinical correlation: a report from Children's Oncology Group study ARST0332
- Creators
- M Beth McCarville - St. Jude Children's Research HospitalSimon C Kao - University of IowaTuan V Dao - Children's Hospital of Orange CountyChristopher Gaffney - Texas Children's HospitalCheryl M Coffin - Vanderbilt UniversityDavid M Parham - Children's Hospital of Los AngelesAndrea Hayes-Jordan - The University of Texas MD Anderson Cancer CenterSheri L Spunt - Stanford University
- Resource Type
- Journal article
- Publication Details
- Pediatric radiology, Vol.49(7), pp.922-932
- DOI
- 10.1007/s00247-019-04389-2
- PMID
- 30929036
- PMCID
- PMC6576270
- NLM abbreviation
- Pediatr Radiol
- ISSN
- 0301-0449
- eISSN
- 1432-1998
- Grant note
- U10 CA098413 / NCI NIH HHS U10CA180899 / NCI NIH HHS U10 CA180886 / NCI NIH HHS U10CA98543 / NCI NIH HHS U10CA180886 / NCI NIH HHS U10 CA180899 / NCI NIH HHS U10CA98413 / NCI NIH HHS U10 CA098543 / NCI NIH HHS
- Language
- English
- Date published
- 06/2019
- Academic Unit
- Radiology; Stead Family Department of Pediatrics
- Record Identifier
- 9984318818102771
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