Magnetic resonance disease severity scale (MRDSS) for patients with multiple sclerosis: A longitudinal study

Jennifer Moodie; Brian C. Healy; Guy J. Buckle; Susan A. Gauthier; Bonnie I. Glanz; Ashish Arora; Antonia Ceccarelli; Shahamat Tauhid; Xue-Mei Han; Arun Venkataraman; Tanuja Chitnis; Samia J. Khoury; Charles R.G. Guttmann; Howard L. Weiner; Mohit Neema; Rohit Bakshi

doi:10.1016/j.jns.2011.11.040

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Magnetic resonance disease severity scale (MRDSS) for patients with multiple sclerosis: A longitudinal study

Journal article

Peer reviewed

Magnetic resonance disease severity scale (MRDSS) for patients with multiple sclerosis: A longitudinal study

Jennifer Moodie, Brian C. Healy, Guy J. Buckle, Susan A. Gauthier, Bonnie I. Glanz, Ashish Arora, Antonia Ceccarelli, Shahamat Tauhid, Xue-Mei Han, Arun Venkataraman, …

Journal of the neurological sciences, Vol.315(1-2), pp.49-54

04/15/2012

DOI: 10.1016/j.jns.2011.11.040

PMCID: PMC3319060

PMID: 22209496

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https://www.ncbi.nlm.nih.gov/pmc/articles/3319060View

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Abstract

We previously described a composite MRI scale combining T1-lesions, T2-lesions and whole brain atrophy in multiple sclerosis (MS): the magnetic resonance disease severity scale (MRDSS). Test strength of the MRDSS vs. individual MRI measures for sensitivity to longitudinal change. We studied 84 MS patients over a 3.2±0.3year follow-up. Baseline and follow-up T2-lesion volume (T2LV), T1-hypointense lesion volume (T1LV), and brain parenchymal fraction (BPF) were measured. MRDSS was the combination of standardized T2LV, T1/T2 ratio and BPF. Patients had higher MRDSS at follow-up vs. baseline (p<0.001). BPF decreased (p<0.001), T1/T2 increased (p<0.001), and T2LV was unchanged (p>0.5). Change in MRDSS was larger than the change in MRI subcomponents. While MRDSS showed significant change in relapsing–remitting (RR) (p<0.001) and secondary progressive (SP) phenotypes (p<0.05), BPF and T1/T2 ratio changed only in RRMS (p<0.001). Longitudinal change in MRDSS was significantly different between RRMS and SPMS (p=0.0027); however, change in the individual MRI components did not differ. Evaluation with respect to predicting on-study clinical worsening as measured by EDSS revealed a significant association only for T2LV (p=0.038). Results suggest improved sensitivity of MRDSS to longitudinal change vs. individual MRI measures. MRDSS has particularly high sensitivity in RRMS.

Brain atrophy

Measurement scales

MRI

Multiple sclerosis

Neurologic disability

T1 hypointense lesions

T2 hyperintense lesions

Details

Title: Subtitle: Magnetic resonance disease severity scale (MRDSS) for patients with multiple sclerosis: A longitudinal study
Creators: Jennifer Moodie - University of Massachusetts Boston
Brian C. Healy - Brigham and Women's Hospital
Guy J. Buckle - Brigham and Women's Hospital
Susan A. Gauthier - Judith Jaffe Multiple Sclerosis Center, Weill Cornell Medical College, New York, USA
Bonnie I. Glanz - Brigham and Women's Hospital
Ashish Arora - Brigham and Women's Hospital
Antonia Ceccarelli - Brigham and Women's Hospital
Shahamat Tauhid - Brigham and Women's Hospital
Xue-Mei Han - Brigham and Women's Hospital
Arun Venkataraman - Brigham and Women's Hospital
Tanuja Chitnis - Brigham and Women's Hospital
Samia J. Khoury - Brigham and Women's Hospital
Charles R.G. Guttmann - Brigham and Women's Hospital
Howard L. Weiner - Brigham and Women's Hospital
Mohit Neema - Brigham and Women's Hospital
Rohit Bakshi - Brigham and Women's Hospital
Resource Type: Journal article
Publication Details: Journal of the neurological sciences, Vol.315(1-2), pp.49-54
DOI: 10.1016/j.jns.2011.11.040
PMID: 22209496
PMCID: PMC3319060
NLM abbreviation: J Neurol Sci
ISSN: 0022-510X
eISSN: 1878-5883
Publisher: Elsevier B.V
Language: English
Date published: 04/15/2012
Academic Unit: Psychiatry
Record Identifier: 9984627315002771

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