Magnetic resonance imaging correlates of set shifting

JOEL H KRAMER; LOVINGLY QUITANIA; DAVID DEAN; JOHN NEUHAUS; HOWARD J ROSEN; CATHRA HALABI; MICHAEL W WEINER; VINCENT A MAGNOTTA; DEAN C DELIS; BRUCE L MILLER

doi:10.1017/S1355617707070567

Journal article

Magnetic resonance imaging correlates of set shifting

JOEL H KRAMER, LOVINGLY QUITANIA, DAVID DEAN, JOHN NEUHAUS, HOWARD J ROSEN, CATHRA HALABI, MICHAEL W WEINER, VINCENT A MAGNOTTA, DEAN C DELIS and BRUCE L MILLER

Journal of the International Neuropsychological Society, Vol.13(3), pp.386-392

05/2007

DOI: 10.1017/S1355617707070567

PMCID: PMC2443737

PMID: 17445286

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https://www.ncbi.nlm.nih.gov/pmc/articles/2443737View

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Abstract

The purpose of this study was to examine the relationships between lobar volumes and set shifting. We studied 101 subjects, including 36 normal controls, 16 patients with probable Alzheimer’s disease, 30 patients with frontotemporal dementia (FTD), and 19 patients with semantic dementia (SD), using a shifting paradigm that carefully controlled for component abilities. Subjects were administered two conditions of the Delis-Kaplan Executive Function System (D-KEFS) Design Fluency Test. In the control condition (DF:Control), examinees generated as many unique designs as possible in 60 s by drawing lines connecting only unfilled dots. In the switching condition (DF:Switch), examinees generated designs by drawing lines alternating between filled and unfilled dots. We used BRAINS2 software to generate volumes of the right and left frontal, temporal, and parietal lobes. Partial correlations and multiple regressions showed that, after controlling for Mini-Mental State Examination and DF:Control, only the right and left frontal lobe volumes significantly correlated with the DF:Switch, most clearly in the FTD and SD groups. Follow-up analyses indicated that frontal contributions to shifting were not related to working memory. Results highlight the importance of carefully controlling for component cognitive processes when studying executive functioning.

Design fluency

BRAINS2

Frontal lobes

D-KEFS

FTD

Details

Title: Subtitle: Magnetic resonance imaging correlates of set shifting
Creators: JOEL H KRAMER - Department of Neurology, University of California San Francisco, San Francisco, California
LOVINGLY QUITANIA - Department of Neurology, University of California San Francisco, San Francisco, California
DAVID DEAN - Department of Neurology, University of California San Francisco, San Francisco, California
JOHN NEUHAUS - Department of Neurology, University of California San Francisco, San Francisco, California
HOWARD J ROSEN - Department of Neurology, University of California San Francisco, San Francisco, California
CATHRA HALABI - Department of Neurology, University of California San Francisco, San Francisco, California
MICHAEL W WEINER - Department of Radiology, University of California San Francisco, San Francisco, California
VINCENT A MAGNOTTA - Department of Radiology, University of Iowa, Iowa City, Iowa
DEAN C DELIS - Department of Psychiatry, University of California San Diego, San Diego, California
BRUCE L MILLER - Department of Neurology, University of California San Francisco, San Francisco, California
Resource Type: Journal article
Publication Details: Journal of the International Neuropsychological Society, Vol.13(3), pp.386-392
DOI: 10.1017/S1355617707070567
PMID: 17445286
PMCID: PMC2443737
NLM abbreviation: J Int Neuropsychol Soc
ISSN: 1355-6177
eISSN: 1469-7661
Language: English
Date published: 05/2007
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Psychiatry; Iowa Neuroscience Institute
Record Identifier: 9984051796902771

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