Journal article
Magnetic resonance imaging in familial versus sporadic cases of schizophrenia
Psychiatry research, Vol.54(1), pp.25-36
1994
DOI: 10.1016/0165-1781(94)90062-0
PMID: 7701026
Abstract
Magnetic resonance imaging findings were compared in 22 familial and 29 sporadic cases with
DSM-III-R diagnosis of schizophrenia, schizoaffective, or schizophreniform disorders. Volumetric measurements were used to assess the size of brain structures, including the cranium, cerebrum, lateral ventricles, temporal horns, third ventricle, lenticular nuclei, amygdaloid-hippocampal complex, and cerebellum, as well as the asymmetry of the lateral ventricles. Increased volume of the lenticular nuclei and greater ventricular asymmetry (the left ventricle being larger) were found in familial cases compared with sporadic cases and normal control subjects. It is possible that increased lenticular nuclei volume and greater lateral ventricular asymmetry reflect the role of genetic factors in schizophrenia.
Details
- Title: Subtitle
- Magnetic resonance imaging in familial versus sporadic cases of schizophrenia
- Creators
- Marc-André Roy - Marc-André Roy, M.D., is Associate Professor of Psychiatry, Centre de Recherche Université Laval Robert-Giffard, Beauport, Québec, CanadaMichael A Flaum - Michael A. Flaum, M.D., is Clinical Director, Mental Health Clinical Research Center, and Associate Professor, Department of Psychiatry, CanadaStephan V Arndt - Stephan V. Arndt, is Adjunct Associate Professor, Department of Preventive Medicine, CanadaRaymond R Crowe - Raymond R. Crowe, M.D., is Professor, Department of Psychiatry, CanadaNancy C Andreasen - Nancy C. Andreasen, M.D., Ph.D., is Director, Mental Health Clinical Research Center, Department of Psychiatry, University of Iowa College of Medicine, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Psychiatry research, Vol.54(1), pp.25-36
- DOI
- 10.1016/0165-1781(94)90062-0
- PMID
- 7701026
- NLM abbreviation
- Psychiatry Res
- ISSN
- 0165-1781
- eISSN
- 1872-7123
- Publisher
- Elsevier Ireland Ltd
- Language
- English
- Date published
- 1994
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute; Biostatistics; Nursing; Injury Prevention Research Center
- Record Identifier
- 9984004081402771
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