Journal article
Magnetic resonance imaging with hyperpolarized agents: methods and applications
Physics in medicine & biology, Vol.62(13), pp.R81-R123
07/07/2017
DOI: 10.1088/1361-6560/aa6be8
PMCID: PMC5730331
PMID: 28384123
Abstract
In the past decade, hyperpolarized (HP) contrast agents have been under active development for MRI applications to address the twin challenges of functional and quantitative imaging. Both HP helium (He-3) and xenon (Xe-129) gases have reached the stage where they are under study in clinical research. HP Xe-129, in particular, is poised for larger scale clinical research to investigate asthma, chronic obstructive pulmonary disease, and fibrotic lung diseases. With advances in polarizer technology and unique capabilities for imaging of Xe-129 gas exchange into lung tissue and blood, HP Xe-129 MRI is attracting new attention. In parallel, HP C-13 and N-15 MRI methods have steadily advanced in a wide range of pre-clinical research applications for imaging metabolism in various cancers and cardiac disease. The HP [1-C-13] pyruvate MRI technique, in particular, has undergone phase I trials in prostate cancer and is poised for investigational new drug trials at multiple institutions in cancer and cardiac applications. This review treats the methodology behind both HP gases and HP C-13 and N-15 liquid state agents. Gas and liquid phase HP agents share similar technologies for achieving non-equilibrium polarization outside the field of the MRI scanner, strategies for image data acquisition, and translational challenges in moving from pre-clinical to clinical research. To cover the wide array of methods and applications, this review is organized by numerical section into (1) a brief introduction, (2) the physical and biological properties of the most common polarized agents with a brief summary of applications and methods of polarization, (3) methods for image acquisition and reconstruction specific to improving data acquisition efficiency for HP MRI, (4) the main physical properties that enable unique measures of physiology or metabolic pathways, followed by a more detailed review of the literature describing the use of HP agents to study: (5) metabolic pathways in cancer and cardiac disease and (6) lung function in both pre-clinical and clinical research studies, concluding with (7) some future directions and challenges, and (8) an overall summary.
Details
- Title: Subtitle
- Magnetic resonance imaging with hyperpolarized agents: methods and applications
- Creators
- Erin B. Adamson - University of Wisconsin–MadisonKai D. Ludwig - University of Wisconsin–MadisonDavid G. Mummy - University of Wisconsin–MadisonSean B. Fain - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- Physics in medicine & biology, Vol.62(13), pp.R81-R123
- DOI
- 10.1088/1361-6560/aa6be8
- PMID
- 28384123
- PMCID
- PMC5730331
- NLM abbreviation
- Phys Med Biol
- ISSN
- 0031-9155
- eISSN
- 1361-6560
- Publisher
- Iop Publishing Ltd
- Number of pages
- 43
- Grant note
- UL1TR000427; TL1TR000429 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA AAPM Graduate Fellowship T32CA009206 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) S10OD016394 / OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Department of Medical Physics in the School of Medicine and Public Health at the University of Wisconsin-Madison R01DK073680 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) GE Healthcare; General Electric Hartwell Foundation TL1TR000429 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) R01HL126771 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Language
- English
- Date published
- 07/07/2017
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health, Sport, and Human Physiology
- Record Identifier
- 9984275060002771
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