Journal article
Magnetic resonance microscopy for monitoring osteogenesis in tissue-engineered construct in vitro
Physics in medicine & biology, Vol.51(3), pp.719-732
02/07/2006
DOI: 10.1088/0031-9155/51/3/016
PMID: 16424591
Abstract
Magnetic resonance microscopy (MRM) is used to monitor osteogenesis in tissue-engineered constructs. Measurements of the developing tissue's MR relaxation times (T(1) and T(2)), apparent diffusion coefficient (ADC) and elastic shear modulus were conducted over a 4-week growth period using an 11.74 T Bruker spectrometer with an imaging probe adapted for MR elastography (MRE). Both the relaxation times and the ADC show a statistically significant decrease after only one week of tissue development while the tissue stiffness increases progressively during the first two weeks of in vitro growth. The measured MR parameters are correlated with histologically monitored osteogenic tissue development. This study shows that MRM can provide quantitative data with which to characterize the growth and development of tissue-engineered bone.
Details
- Title: Subtitle
- Magnetic resonance microscopy for monitoring osteogenesis in tissue-engineered construct in vitro
- Creators
- Huihui Xu - University of Illinois ChicagoShadi F Othman - University of Illinois ChicagoLiu Hong - University of Illinois ChicagoIoana A Peptan - University of Illinois ChicagoRichard L Magin - University of Illinois Chicago
- Resource Type
- Journal article
- Publication Details
- Physics in medicine & biology, Vol.51(3), pp.719-732
- DOI
- 10.1088/0031-9155/51/3/016
- PMID
- 16424591
- NLM abbreviation
- Phys Med Biol
- ISSN
- 0031-9155
- eISSN
- 1361-6560
- Language
- English
- Date published
- 02/07/2006
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Prosthodontics; Craniofacial Anomalies Research Center; Dental Research
- Record Identifier
- 9984367743502771
Metrics
3 Record Views