Magnetic stereotaxis: a technique to deliver stereotactic hyperthermia

M Sean Grady; Matthew A Howard III; William C Broaddus; Janelle A Molloy; Rogers C Ritter; Elizabeth G Quate; George T Gillies

doi:10.1097/00006123-199012000-00026

Back

Magnetic stereotaxis: a technique to deliver stereotactic hyperthermia

Journal article

Peer reviewed

Magnetic stereotaxis: a technique to deliver stereotactic hyperthermia

M Sean Grady, Matthew A Howard III, William C Broaddus, Janelle A Molloy, Rogers C Ritter, Elizabeth G Quate and George T Gillies

Neurosurgery, Vol.27(6), pp.1010-5; discussion 1015-6

12/1990

DOI: 10.1097/00006123-199012000-00026

PMID: 2274121

View Online

Abstract

Advances in imaging techniques and computer software over the past decade now define brain abnormalities such as tumors in precise, three-dimensional images. We have taken advantage of these technological improvements in designing a system capable of performing magnetic manipulation of an object in a nonlinear trajectory and able to deliver hyperthermia to highly specific targets within the brain. This device relies on external magnets to pull a small metal pellet (thermoceptor) through the brain, and on biplane fluoroscopy to localize the thermoceptor with respect to previously obtained magnetic resonance images. A radiofrequency tuned circuit serves as the hyperthermia applicator and selectively heats the thermoceptor. This paper describes experiments conducted in a series of dogs showing that all three components of the system (magnetic drive, stereotactic real time imaging, and hyperthermia) can be achieved. Integration of the system was accomplished in one animal. These encouraging results need further detailed substantiation in each of the components, yet demonstrate the feasibility of such a device.

Magnetic Resonance Imaging

Magnetics

Animals

Hyperthermia, Induced - instrumentation

Dogs

Brain - pathology

Calibration

Equipment Design

Stereotaxic Techniques - instrumentation

Details

Title: Subtitle: Magnetic stereotaxis: a technique to deliver stereotactic hyperthermia
Creators: M Sean Grady - Department of Neurological Surgery, University of Washington, Seattle
Matthew A Howard III
William C Broaddus
Janelle A Molloy
Rogers C Ritter
Elizabeth G Quate
George T Gillies
Resource Type: Journal article
Publication Details: Neurosurgery, Vol.27(6), pp.1010-5; discussion 1015-6
Publisher: United States
DOI: 10.1097/00006123-199012000-00026
PMID: 2274121
ISSN: 0148-396X
eISSN: 1524-4040
Grant note: NSO1371 / NINDS NIH HHS
Language: English
Date published: 12/1990
Academic Unit: Neurology; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
Record Identifier: 9984020871102771

Metrics

18 Record Views

19 Times Cited - Web of Science