Journal article
Magnetically steered cell therapy for reduction of intraocular pressure as a treatment strategy for open-angle glaucoma
eLife, Vol.13, RP103256
07/07/2025
DOI: 10.7554/eLife.103256.3
Abstract
Trabecular meshwork (TM) cell therapy has been proposed as a next-generation treatment for elevated intraocular pressure (IOP) in glaucoma, the most common cause of irreversible blindness. Using a magnetic cell steering technique with excellent efficiency and tissue-specific targeting, we delivered two types of cells into a mouse model of glaucoma: either human adipose-derived mesenchymal stem cells (hAMSCs) or induced pluripotent cell derivatives (iPSC-TM cells). We observed a 4.5 [3.1, 6.0] mmHg or 27% reduction in intraocular pressure (IOP) for 9 months after a single dose of only 1500 magnetically steered hAMSCs, explained by increased outflow through the conventional pathway and associated with a higher TM cellularity. iPSC-TM cells were also effective, but less so, showing only a 1.9 [0.4, 3.3] mmHg or 13% IOP reduction and increased risk of tumorigenicity. In both cases, injected cells remained detectable in the iridocorneal angle 3 weeks post-transplantation. Based on the locations of the delivered cells, the mechanism of IOP lowering is most likely paracrine signaling. We conclude that magnetically steered hAMSC cell therapy has potential for long-term treatment of ocular hypertension in glaucoma.
Details
- Title: Subtitle
- Magnetically steered cell therapy for reduction of intraocular pressure as a treatment strategy for open-angle glaucoma
- Creators
- M Reza Bahranifard - Georgia Institute of TechnologyJessica Chan - Georgia Institute of TechnologyA Thomas Read - The Wallace H. Coulter Department of Biomedical EngineeringGuorong Li - Duke UniversityLin Cheng - Iowa City VA Health Care SystemBabak N Safa - The Wallace H. Coulter Department of Biomedical EngineeringSeyed Mohammad Siadat - The Wallace H. Coulter Department of Biomedical EngineeringAnamik Jhunjhunwala - The Wallace H. Coulter Department of Biomedical EngineeringHans E Grossniklaus - Emory UniversityStanislav Y Emelianov - The Wallace H. Coulter Department of Biomedical EngineeringW Daniel Stamer - Duke UniversityMarkus H Kuehn - University of IowaC Ross Ethier - Georgia Institute of Technology
- Resource Type
- Journal article
- Publication Details
- eLife, Vol.13, RP103256
- DOI
- 10.7554/eLife.103256.3
- ISSN
- 2050-084X
- eISSN
- 2050-084X
- Language
- English
- Date published
- 07/07/2025
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9984845654602771
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