Journal article
Magnetically vectored nanocapsules for tumor penetration and remotely switchable on-demand drug release
Nano letters, Vol.10(12), pp.5088-5092
12/08/2010
DOI: 10.1021/nl1033733
PMID: 21038917
Abstract
Nanocapsules containing intentionally trapped magnetic nanoparticles and defined anticancer drugs have been prepared to provide a powerful magnetic vector under moderate gradient magnetic fields. These nanocapsules can penetrate into the interior of tumors and allow a controlled on-off switchable release of the drug cargo via remote RF field. This smart drug delivery system is compact as all the components can be self-contained in 80-150 nm capsules. In vitro as well as in vivo results indicate that these nanocapsules can be enriched near the mouse breast tumor and are effective in reducing tumor cell growth.
Details
- Title: Subtitle
- Magnetically vectored nanocapsules for tumor penetration and remotely switchable on-demand drug release
- Creators
- Seong Deok Kong - Materials Science and EngineeringWeizhou ZhangJun Hee LeeKarla BrammerRatnesh LalMichael KarinSungho Jin
- Resource Type
- Journal article
- Publication Details
- Nano letters, Vol.10(12), pp.5088-5092
- DOI
- 10.1021/nl1033733
- PMID
- 21038917
- NLM abbreviation
- Nano Lett
- ISSN
- 1530-6984
- eISSN
- 1530-6992
- Language
- English
- Date published
- 12/08/2010
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984083883502771
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