Maintenance Antiretroviral Therapies in HIV-Infected Subjects with Undetectable Plasma HIV RNA after Triple-Drug Therapy

Diane V Havlir; Ian C Marschner; Martin S Hirsch; Ann C Collier; Pablo Tebas; Roland L Bassett; John P.A Ioannidis; M.K Holohan; Randi Leavitt; Gloria Boone; Douglas D Richman; AIDS Clinical Trials Group Study 343 Team

doi:10.1056/NEJM199810293391801

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Maintenance Antiretroviral Therapies in HIV-Infected Subjects with Undetectable Plasma HIV RNA after Triple-Drug Therapy

Journal article

Open access

Peer reviewed

Maintenance Antiretroviral Therapies in HIV-Infected Subjects with Undetectable Plasma HIV RNA after Triple-Drug Therapy

Diane V Havlir, Ian C Marschner, Martin S Hirsch, Ann C Collier, Pablo Tebas, Roland L Bassett, John P.A Ioannidis, M.K Holohan, Randi Leavitt, Gloria Boone, …

The New England journal of medicine, Vol.339(18), pp.1261-1268

10/29/1998

DOI: 10.1056/NEJM199810293391801

PMID: 9791141

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Abstract

Combination antiretroviral regimens effectively reduce levels of human immunodeficiency virus (HIV) RNA in the plasma and lymph nodes, improve immune function, and delay the progression of HIV disease. 1 – 5 The recent recognition that a long-lived reservoir of HIV persists in latently infected CD4 cells, even among patients in whom HIV replication has been suppressed for two years, suggests the need for continued HIV therapy for many years, if not for life. 6 – 8 Regimens with multiple drugs are difficult for patients to adhere to and are associated with toxic effects and high cost. Simplified HIV-treatment strategies are needed. The success of . . .

Details

Title: Subtitle: Maintenance Antiretroviral Therapies in HIV-Infected Subjects with Undetectable Plasma HIV RNA after Triple-Drug Therapy
Creators: Diane V Havlir
Ian C Marschner
Martin S Hirsch
Ann C Collier
Pablo Tebas
Roland L Bassett
John P.A Ioannidis
M.K Holohan
Randi Leavitt
Gloria Boone
Douglas D Richman
AIDS Clinical Trials Group Study 343 Team
Contributors: J Stapleton (Contributor) - University of Iowa, Internal Medicine
Resource Type: Journal article
Publication Details: The New England journal of medicine, Vol.339(18), pp.1261-1268
DOI: 10.1056/NEJM199810293391801
PMID: 9791141
NLM abbreviation: N Engl J Med
ISSN: 0028-4793
eISSN: 1533-4406
Publisher: Massachusetts Medical Society
Language: English
Date published: 10/29/1998
Academic Unit: Microbiology and Immunology; Infectious Diseases; Internal Medicine
Record Identifier: 9984094549002771

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