Journal article
Maintenance of complex neural function during perfusion of the mammalian brain
Brain research, Vol.409(1), pp.128-132
1987
DOI: 10.1016/0006-8993(87)90747-5
PMID: 3580861
Abstract
A perfused brain preparation was developed utilizing non-pulsatile flow of artificial blood. Cortical electrical activity and respiratory motor output were maintained for as long as 7–8 h. This preparation permits stable intracellular recordings from CNS neurons displaying ongoing respiratory activity, and should permit analysis of synaptic and intrinsic cellular mechanisms involved in producing the respiratory output. A similar approach may be useful for electrophysiology throughout the CNS, and for other fields in which control of the blood composition and/or mechanical stability are required.
Details
- Title: Subtitle
- Maintenance of complex neural function during perfusion of the mammalian brain
- Creators
- George B RichersonPeter A Getting
- Resource Type
- Journal article
- Publication Details
- Brain research, Vol.409(1), pp.128-132
- Publisher
- Elsevier B.V
- DOI
- 10.1016/0006-8993(87)90747-5
- PMID
- 3580861
- ISSN
- 0006-8993
- eISSN
- 1872-6240
- Language
- English
- Date published
- 1987
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984020716202771
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