Journal article
Maintenance of genome integrity by the late-acting cytoplasmic iron-sulfur assembly (CIA) complex
Frontiers in genetics, Vol.14, pp.1152398-1152398
03/08/2023
DOI: 10.3389/fgene.2023.1152398
PMCID: PMC10031043
PMID: 36968611
Abstract
Iron-sulfur (Fe-S) clusters are unique, redox-active co-factors ubiquitous throughout cellular metabolism. Fe-S cluster synthesis, trafficking, and coordination result from highly coordinated, evolutionarily conserved biosynthetic processes. The initial Fe-S cluster synthesis occurs within the mitochondria; however, the maturation of Fe-S clusters culminating in their ultimate insertion into appropriate cytosolic/nuclear proteins is coordinated by a late-acting cytosolic iron-sulfur assembly (CIA) complex in the cytosol. Several nuclear proteins involved in DNA replication and repair interact with the CIA complex and contain Fe-S clusters necessary for proper enzymatic activity. Moreover, it is currently hypothesized that the late-acting CIA complex regulates the maintenance of genome integrity and is an integral feature of DNA metabolism. This review describes the late-acting CIA complex and several [4Fe-4S] DNA metabolic enzymes associated with maintaining genome stability.
Details
- Title: Subtitle
- Maintenance of genome integrity by the late-acting cytoplasmic iron-sulfur assembly (CIA) complex
- Creators
- M. S. Petronek - University of IowaB. G. Allen - , , , , ,
- Resource Type
- Journal article
- Publication Details
- Frontiers in genetics, Vol.14, pp.1152398-1152398
- DOI
- 10.3389/fgene.2023.1152398
- PMID
- 36968611
- PMCID
- PMC10031043
- NLM abbreviation
- Front Genet
- ISSN
- 1664-8021
- eISSN
- 1664-8021
- Publisher
- Frontiers Media S.A
- Grant note
- T32 CA078586 P01 CA217797 G-17-1500 / ;
- Alternative title
- Petronek and Allen
- Language
- English
- Date published
- 03/08/2023
- Academic Unit
- Iowa Neuroscience Institute; Radiation Oncology
- Record Identifier
- 9984446518902771
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