Major Chromosomal Anomalies among Very Low Birth Weight Infants in the Vermont Oxford Network

Nansi S Boghossian; Jeffrey D Horbar; Joseph H Carpenter; Jeffrey C Murray; Edward F Bell

doi:10.1016/j.jpeds.2011.11.005

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Major Chromosomal Anomalies among Very Low Birth Weight Infants in the Vermont Oxford Network

Journal article

Open access

Peer reviewed

Major Chromosomal Anomalies among Very Low Birth Weight Infants in the Vermont Oxford Network

Nansi S Boghossian, Jeffrey D Horbar, Joseph H Carpenter, Jeffrey C Murray and Edward F Bell

The Journal of pediatrics, Vol.160(5), pp.774-780.e11

05/2012

DOI: 10.1016/j.jpeds.2011.11.005

PMCID: PMC3646085

PMID: 22177989

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https://www.ncbi.nlm.nih.gov/pmc/articles/3646085View

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Abstract

To examine prevalence, characteristics, interventions, and mortality of very low birth weight (VLBW) infants with trisomy 21 (T21), trisomy 18 (T18), trisomy 13 (T13), or triploidy. Infants with birth weight 401-1500 g admitted to centers of the Vermont Oxford Network during 1994-2009 were studied. A majority of the analyses are presented as descriptive data. Median survival times and their 95% CIs were estimated using the Kaplan-Meier approach. Of 539 509 VLBW infants, 1681 (0.31%) were diagnosed with T21, 1416 (0.26%) with T18, 435 (0.08%) with T13, and 116 (0.02%) with triploidy. Infants with T18 were the most likely to be growth restricted (79.7%). Major surgery was reported for 30.4% of infants with T21, 9.2% with T18, 6.4% with T13, and 4.8% with triploidy. Hospital mortality occurred among 33.1% of infants with T21, 89.0% with T18, 92.4% with T13, and 90.5% with triploidy. Median survival time was 4 days (95% CI, 3-4) among infants with T18 and 3 days (95% CI, 2-4) among both infants with T13 and infants with triploidy. In this cohort of VLBW infants, survival among infants with T18, T13, or triploidy was very poor. This information can be used to counsel families.

VLBW

NICU

PDA

SGA

LOHS

NEC

Dr.

ROP

T21

VON

T13

T18

CHD

Details

Title: Subtitle: Major Chromosomal Anomalies among Very Low Birth Weight Infants in the Vermont Oxford Network
Creators: Nansi S Boghossian - Department of Pediatrics, University of Iowa, Iowa City, Iowa
Jeffrey D Horbar - Vermont Oxford Network, Burlington, VT
Joseph H Carpenter - Vermont Oxford Network, Burlington, VT
Jeffrey C Murray - Department of Pediatrics, University of Iowa, Iowa City, Iowa
Edward F Bell - Department of Pediatrics, University of Iowa, Iowa City, Iowa
Resource Type: Journal article
Publication Details: The Journal of pediatrics, Vol.160(5), pp.774-780.e11
DOI: 10.1016/j.jpeds.2011.11.005
PMID: 22177989
PMCID: PMC3646085
NLM abbreviation: J Pediatr
ISSN: 0022-3476
eISSN: 1097-6833
Publisher: Elsevier Inc
Language: English
Date published: 05/2012
Academic Unit: Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research; Neonatology
Record Identifier: 9984025367502771

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