Major Hepatectomy Induces Phenotypic Changes in Circulating Dendritic Cells and Monocytes

Philip A. Efron; Tadashi Matsumoto; Priscilla F. McAuliffe; Philip Scumpia; Ricardo Ungaro; Shiro Fujita; Lyle L. Moldawer; David Foley; Alan W. Hemming

doi:10.1007/s10875-009-9291-y

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Major Hepatectomy Induces Phenotypic Changes in Circulating Dendritic Cells and Monocytes

Journal article

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Major Hepatectomy Induces Phenotypic Changes in Circulating Dendritic Cells and Monocytes

Philip A. Efron, Tadashi Matsumoto, Priscilla F. McAuliffe, Philip Scumpia, Ricardo Ungaro, Shiro Fujita, Lyle L. Moldawer, David Foley and Alan W. Hemming

Journal of clinical immunology, Vol.29(5), pp.568-581

09/01/2009

DOI: 10.1007/s10875-009-9291-y

PMCID: PMC3971576

PMID: 19387804

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https://www.ncbi.nlm.nih.gov/pmc/articles/3971576View

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Abstract

Patients undergoing major hepatectomy are at increased risk for post-operative morbidity and mortality, and changes in the phenotype of effector cells may predispose these patients to infectious sequelae. To better understand post-hepatectomy immune responses, peripheral blood from 15 hepatectomy patients was drawn immediately before and after liver resection and on post-operative days 1, 3, and 5. Circulating monocytes and dendritic cells were analyzed by flow cytometry for quantity, phenotype, activation status, human leukocyte antigen DR (HLA-DR) expression, and toll-like receptor-2 and -4 expression. Major hepatectomy increased the numbers of activated CD16(bright) blood monocytes and the percentage of activated dendritic cells, although monocyte HLA-DR expression was reduced. These results may represent both dysfunctional antigen presentation and pending anergy, as well as cellular priming of immune effector cells. Better understanding of the alterations in innate immunity induced by hepatectomy may identify strategies to reduce infectious outcomes.

Immunology

Life Sciences & Biomedicine

Science & Technology

Details

Title: Subtitle: Major Hepatectomy Induces Phenotypic Changes in Circulating Dendritic Cells and Monocytes
Creators: Philip A. Efron - University of Florida
Tadashi Matsumoto - University of Florida
Priscilla F. McAuliffe - University of Florida
Philip Scumpia - University of Florida
Ricardo Ungaro - University of Florida
Shiro Fujita - University of Florida
Lyle L. Moldawer - University of Florida
David Foley - University of Florida
Alan W. Hemming - University of Florida
Resource Type: Journal article
Publication Details: Journal of clinical immunology, Vol.29(5), pp.568-581
DOI: 10.1007/s10875-009-9291-y
PMID: 19387804
PMCID: PMC3971576
NLM abbreviation: J Clin Immunol
ISSN: 0271-9142
eISSN: 1573-2592
Publisher: Springer Nature
Number of pages: 14
Grant note: R37 GM-40561-15; R01 GM-63212-03; T32 GM-08721-05 / National Institute of General Medical Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) T32GM008721 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS)
Language: English
Date published: 09/01/2009
Academic Unit: Surgery
Record Identifier: 9984322822302771

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