Journal article
Major depression and electrovestibulography
The world journal of biological psychiatry, Vol.16(5), pp.334-350
08/01/2015
DOI: 10.3109/15622975.2015.1014410
PMID: 25815564
Abstract
Objectives. No electrophysiological neuroimaging or genetic markers have been established that strongly relate to a diagnosis of major depression or its severity. The objective of this paper is to describe the preliminary evaluation of a potential new biomarker for depression utilizing the recording of electrical activity from the outer ear canal referred to as electrovestibulography (EVestG). Methods. Sensory oto-acoustic features were extracted from EVestG data to compare 31 healthy age- and gender-matched individuals as controls to 43 major depressive disorder (MDD) subjects (22 symptomatic (MDD-S), 21 reduced symptomatic (MDD-R)). The stimulus was a single supine-vertical translation. The six features examined were based on the measured firing pattern interval histogram and the shape of the average field potential response. Results. An unbiased classification accuracy of 85, 87 and 77% was achieved for separating Control from MDD-S, Control from MDD, and MDD-S from MDD-R groups respectively. Features used showed low but significant correlations (P < 0.05) with MADRS and CORE assessments. Conclusions. The results support the use of separate features for measuring MDD symptomatology versus diagnosing MDD, representing plausible different mechanisms of brain function in MDD-S and MDD-R. The first evidence of the successful application of sensory oto-acoustic features toward diagnosing and measuring the symptomatology of MDD is presented.
Details
- Title: Subtitle
- Major depression and electrovestibulography
- Creators
- Brian J. Lithgow - Riverview HospitalAmber L. Garrett - Monash UniversityZahra M. Moussavi - University of ManitobaCaroline Gurvich - Monash Alfred Psychiatry Research centreJayashri Kulkarni - Monash Alfred Psychiatry Research centreJerome J. Maller - Monash Alfred Psychiatry Research centrePaul B. Fitzgerald - Monash Alfred Psychiatry Research centre
- Resource Type
- Journal article
- Publication Details
- The world journal of biological psychiatry, Vol.16(5), pp.334-350
- DOI
- 10.3109/15622975.2015.1014410
- PMID
- 25815564
- NLM abbreviation
- World J Biol Psychiatry
- ISSN
- 1562-2975
- eISSN
- 1814-1412
- Publisher
- Taylor & Francis
- Number of pages
- 17
- Language
- English
- Date published
- 08/01/2015
- Academic Unit
- Radiology
- Record Identifier
- 9984848501002771
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