Making time and space for calcium control of neuron activity

Joanna Jȩdrzejewska-Szmek; Daniel B. Dorman; Kim T. Blackwell

doi:10.1016/j.conb.2023.102804

Back

Making time and space for calcium control of neuron activity

Journal article

Open access

Peer reviewed

Making time and space for calcium control of neuron activity

Joanna Jȩdrzejewska-Szmek, Daniel B. Dorman and Kim T. Blackwell

Current opinion in neurobiology, Vol.83, pp.102804-102804

12/01/2023

DOI: 10.1016/j.conb.2023.102804

PMCID: PMC10842147

PMID: 37913687

Files and links (1)

url

https://pmc.ncbi.nlm.nih.gov/articles/PMC10842147/pdf/nihms-1938131.pdfView

Open Access

Abstract

Calcium directly controls or indirectly regulates numerous functions that are critical for neuronal network activity. Intracellular calcium concentration is tightly regulated by numerous molecular mechanisms because spatial domains and temporal dynamics (not just peak amplitude) are critical for calcium control of synaptic plasticity and ion channel activation, which in turn determine neuron spiking activity. The computational models investigating calcium control are valuable because experiments achieving high spatial and temporal resolution simultaneously are technically unfeasible. Simulations of calcium nanodomains reveal that specific calcium sources can couple to specific calcium targets, providing a mechanism to determine the direction of synaptic plasticity. Cooperativity of calcium domains opposes specificity, suggesting that the dendritic branch might be the preferred computational unit of the neuron. •Calcium dynamics during in vivo conditions are influenced by immobile buffers and vesicle release.•The size of calcium domains change over time; thus, high specificity coupling evolves to lower specificity activation.•Cooperativity of synaptic inputs opposes spatial specificity, which is restored by inhibitory mechanisms.•Calcium release from stores may promote synaptic plasticity by prolonging the calcium signal.

Calcium release

Computational model

Nanodomains

Stochastic

Synaptic plasticity

Details

Title: Subtitle: Making time and space for calcium control of neuron activity
Creators: Joanna Jȩdrzejewska-Szmek - Instytut Biologii Doświadczalnej im. Marcelego Nenckiego
Daniel B. Dorman - Johns Hopkins University
Kim T. Blackwell - George Mason University
Resource Type: Journal article
Publication Details: Current opinion in neurobiology, Vol.83, pp.102804-102804
DOI: 10.1016/j.conb.2023.102804
PMID: 37913687
PMCID: PMC10842147
NLM abbreviation: Curr Opin Neurobiol
ISSN: 0959-4388
eISSN: 1873-6882
Publisher: Elsevier Ltd
Grant note: DOI: 10.13039/100000002, name: National Institutes of Health, award: 5K12GM123914
Language: English
Date published: 12/01/2023
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Iowa Neuroscience Institute
Record Identifier: 9984573819402771

Metrics

58 Record Views

13 Times Cited - Web of Science

See more details