Maladaptive Self-Focused Attention and Default Mode Network Connectivity: A Transdiagnostic Investigation Across Social Anxiety and Body Dysmorphic Disorders

Angela Fang; Bengi Baran; Clare C Beatty; Jennifer Mosley; Jamie D Feusner; K Luan Phan; Sabine Wilhelm; Dara S Manoach

doi:10.1093/scan/nsab130

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Maladaptive Self-Focused Attention and Default Mode Network Connectivity: A Transdiagnostic Investigation Across Social Anxiety and Body Dysmorphic Disorders

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Maladaptive Self-Focused Attention and Default Mode Network Connectivity: A Transdiagnostic Investigation Across Social Anxiety and Body Dysmorphic Disorders

Angela Fang, Bengi Baran, Clare C Beatty, Jennifer Mosley, Jamie D Feusner, K Luan Phan, Sabine Wilhelm and Dara S Manoach

Social cognitive and affective neuroscience, Vol.17(7), pp.645-654

07/2022

DOI: 10.1093/scan/nsab130

PMCID: PMC9250304

PMID: 34875086

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Abstract

Abstract Maladaptive self-focused attention (SFA) is a bias toward internal thoughts, feelings, and physical states. Despite its role as a core maintaining factor of symptoms in cognitive theories of social anxiety and body dysmorphic disorders, studies have not examined its neural basis. In this study, we hypothesized that maladaptive SFA would be associated with hyperconnectivity in the default mode network (DMN) in self-focused patients with these disorders. Thirty patients with primary social anxiety disorder or primary body dysmorphic disorder, and 28 healthy individuals were eligible and scanned. Eligibility was determined by scoring greater than 1SD or below 1SD of the Public Self-Consciousness Scale normative mean, respectively, for each group. Seed-to-voxel functional connectivity was computed using a DMN posterior cingulate cortex (PCC) seed. There was no evidence of increased DMN functional connectivity in patients compared to controls. Patients (regardless of diagnosis) showed reduced functional connectivity of the PCC with several brain regions, including the bilateral superior parietal lobule (SPL), compared to controls, which was inversely correlated with maladaptive SFA but not associated with social anxiety, body dysmorphic, or depression severity, or rumination. Abnormal PCC-SPL connectivity may represent a transdiagnostic neural marker of SFA that reflects difficulty shifting between internal versus external attention.

Details

Title: Subtitle: Maladaptive Self-Focused Attention and Default Mode Network Connectivity: A Transdiagnostic Investigation Across Social Anxiety and Body Dysmorphic Disorders
Creators: Angela Fang - University of Washington
Bengi Baran - University of Iowa
Clare C Beatty - Stony Brook University
Jennifer Mosley - University of Washington
Jamie D Feusner - Centre for Addiction and Mental Health
K Luan Phan - Department of Psychiatry and Behavioral Health, Ohio State University Wexner Medical Center, Columbus, OH, USA
Sabine Wilhelm - Harvard Medical School
Dara S Manoach - Harvard Medical School
Resource Type: Journal article
Publication Details: Social cognitive and affective neuroscience, Vol.17(7), pp.645-654
DOI: 10.1093/scan/nsab130
PMID: 34875086
PMCID: PMC9250304
NLM abbreviation: Soc Cogn Affect Neurosci
ISSN: 1749-5016
eISSN: 1749-5024
Grant note: DOI: 10.13039/100000025, name: National Institute of Mental Health, award: K23 MH109593
Language: English
Electronic publication date: 12/07/2021
Date published: 07/2022
Academic Unit: Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984201557702771

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