Malondialdehyde production by platelets during secondary aggregation

D E MacFarlane; Sheila Gardner; Carol Lipson; D C B Mills

doi:10.1055/s-0038-1651918

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Malondialdehyde production by platelets during secondary aggregation

Journal article

Peer reviewed

Malondialdehyde production by platelets during secondary aggregation

D E MacFarlane, Sheila Gardner, Carol Lipson and D C B Mills

Thrombosis and haemostasis, Vol.38(4), pp.1002-1009

12/15/1977

DOI: 10.1055/s-0038-1651918

PMID: 579680

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Abstract

A method is described for increasing the sensitivity of the thiobarbiturate assay for malondialdehyde by concentrating the coloured reaction product. The basal level of malondialdehyde-like material in plasma was found to be about 0.03 micrometer. Platelets synthesized malondialdehyde when stimulated by collagen or thrombin and also during the second phase of aggregation induced by ADP or adrenaline.

Malonates - biosynthesis

Platelet Aggregation - drug effects

Malondialdehyde - biosynthesis

Blood Platelets - metabolism

Epinephrine - pharmacology

Adenosine Diphosphate - pharmacology

Details

Title: Subtitle: Malondialdehyde production by platelets during secondary aggregation
Creators: D E MacFarlane
Sheila Gardner
Carol Lipson
D C B Mills
Resource Type: Journal article
Publication Details: Thrombosis and haemostasis, Vol.38(4), pp.1002-1009
DOI: 10.1055/s-0038-1651918
PMID: 579680
ISSN: 0340-6245
eISSN: 2567-689X
Language: English
Date published: 12/15/1977
Academic Unit: Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
Record Identifier: 9984094709802771

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