Journal article
Mammographic densities and risk of breast cancer
Cancer, Vol.67(11), pp.2833-2838
06/01/1991
DOI: 10.1002/1097-0142(19910601)67:11<2833::AID-CNCR2820671121>3.0.CO;2-U
PMID: 2025849
Abstract
To determine the relation of mammographic densities to subsequent breast cancer risk, a case—control study was undertaken using prediagnostic mammograms of screening program participants. Mammograms of cases (n = 266) and controls (n = 301) were blindly assessed for mammographic densities, which were measured by planimetry. The odds of breast cancer increased steadily with increasing breast density (test for trend, P < 0.0001). Breast cancer odds was 1.7 for densities between 5% and 24.9%, 2.5 for 25% through 44.9%, 3.8 for 45% through 64%, and 4.3 for densities of 65% and greater (referent = <5% densities). Odds ratios also increased with increasing densities among women with the P2 and DY mammographic patterns. These findings suggest that the percentage of mammographic densities in the breast can predict breast cancer risk more accurately than a qualitative assessment of mammographic patterns.
Details
- Title: Subtitle
- Mammographic densities and risk of breast cancer
- Creators
- Audrey F. Saftlas - Centers for Disease Control and PreventionRobert N. Hoover - National Cancer InstituteLouise A. Brinton - National Cancer InstituteMoyses Szklo - National Center for Chronic Disease Prevention and Health PromotionDavid R. OlsonMartine Salane - Johns Hopkins UniversityJohn N. Wolfe
- Resource Type
- Journal article
- Publication Details
- Cancer, Vol.67(11), pp.2833-2838
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company
- DOI
- 10.1002/1097-0142(19910601)67:11<2833::AID-CNCR2820671121>3.0.CO;2-U
- PMID
- 2025849
- ISSN
- 0008-543X
- eISSN
- 1097-0142
- Number of pages
- 6
- Grant note
- Institutional Research Cancer Epidemiology Fellowship (T 32 CA09314‐07) National Cancer Institute
- Language
- English
- Date published
- 06/01/1991
- Academic Unit
- Epidemiology
- Record Identifier
- 9984364432402771
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