Journal article
Management of Mucinous Cystic Neoplasms of the Liver
Journal of gastrointestinal surgery, Vol.27(9), pp.1963-1970
09/01/2023
DOI: 10.1007/s11605-023-05709-6
PMID: 37221388
Abstract
Mucinous cystic neoplasms of the liver (MCN-L) including biliary cystadenomas (BCA) and biliary cystadenocarcinomas (BCAC) are rare cystic lesions that comprise less than 5% of all liver cysts and affect only a small subset of individuals. We herein review the current evidence regarding the clinical presentation, imaging characteristics, tumor markers, pathological findings, clinical management, and prognosis of MCN-L.
A comprehensive review of the literature was performed using MEDLINE/Pubmed and Web of Science databases. In PubMed, the terms "biliary cystadenoma," "biliary cystadenocarcinoma," and "non parasitic hepatic cysts" were queried to identify the most recent data on MCN-L.
US imaging, CT, and MRI, as well as consideration of clinicopathological features, are required to appropriately characterize and diagnose hepatic cystic tumors. BCA are premalignant lesions and cannot be reliably differentiated from BCAC based on imaging alone. As such, both types of lesions should be treated with margin-negative surgical resection. Following surgical resection, recurrence is fairly low among patients with BCA and BCAC. Despite having worse long-term outcomes than BCA, the prognosis following surgical resection of BCAC still remains more favorable than other primary malignant liver tumors.
MCN-L are rare cystic liver tumors that include BCA and BCAC, which can be difficult to differentiate based on imaging alone. Surgical resection remains the mainstay of management for MCN-L with recurrence being generally uncommon. Future multi-institutional studies are still required to better understand the biology behind BCA and BCAC to improve the care of patients with MCN-L.
Details
- Title: Subtitle
- Management of Mucinous Cystic Neoplasms of the Liver
- Creators
- Hassan Aziz - University of IowaAhmad Hamad - The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research InstituteShadi Afyouni - Johns Hopkins MedicineIhab R Kamel - Johns Hopkins MedicineTimothy M Pawlik - The Ohio State University Wexner Medical Center
- Resource Type
- Journal article
- Publication Details
- Journal of gastrointestinal surgery, Vol.27(9), pp.1963-1970
- DOI
- 10.1007/s11605-023-05709-6
- PMID
- 37221388
- ISSN
- 1091-255X
- eISSN
- 1873-4626
- Language
- English
- Date published
- 09/01/2023
- Academic Unit
- Surgery
- Record Identifier
- 9984701543102771
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