Management of neonatal aortic arch thrombosis with low-molecular weight heparin: a case series

Anjali Alatkar Sharathkumar; Nancy Lamear; Steven Pipe; Sanjay Parikh; Mark Russell; Abrahim Simon; Amy Shapiro

doi:10.1097/MPH.0b013e3181a6e030

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Management of neonatal aortic arch thrombosis with low-molecular weight heparin: a case series

Journal article

Peer reviewed

Management of neonatal aortic arch thrombosis with low-molecular weight heparin: a case series

Anjali Alatkar Sharathkumar, Nancy Lamear, Steven Pipe, Sanjay Parikh, Mark Russell, Abrahim Simon and Amy Shapiro

Journal of pediatric hematology/oncology, Vol.31(7), pp.516-521

07/2009

DOI: 10.1097/MPH.0b013e3181a6e030

PMID: 19564749

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Abstract

Aortic arch thrombosis (AAT) is a potentially life threatening condition in neonates. We report 3 neonates with AAT and complete occlusion of a unilateral internal carotid artery with multiple cerebral infarcts. Multidisciplinary input led to deferral of thrombolytic therapy and surgical thrombectomy owing to the potential risk of hemorrhage within the infarcts. All the neonates were treated with low-molecular weight heparin treatment alone without any complications. Thrombus resolution was complete in 2 neonates, whereas it was near complete in one neonate. All the infants showed normal growth and development during follow-up. The rewarding outcome in these cases suggests that treatment with low-molecular weight heparin could be considered an option to treat AAT in selected patients.

Cerebral Infarction - drug therapy

Thrombosis - complications

Humans

Anticoagulants - therapeutic use

Heparin, Low-Molecular-Weight - therapeutic use

Thrombosis - pathology

Aortic Diseases - drug therapy

Carotid Artery Diseases - pathology

Aortic Diseases - complications

Cerebral Infarction - etiology

Thrombosis - drug therapy

Aorta, Thoracic - pathology

Infant, Newborn

Carotid Artery Diseases - drug therapy

Details

Title: Subtitle: Management of neonatal aortic arch thrombosis with low-molecular weight heparin: a case series
Creators: Anjali Alatkar Sharathkumar - Indiana Hemophilia and Thrombosis Centre, St Vincent Women's Hospital parallelChildren's Heart Center, St Vincent Hospitals, Indianapolis, IN 46260, USA. asharathkumar@ihtc.org
Nancy Lamear
Steven Pipe
Sanjay Parikh
Mark Russell
Abrahim Simon
Amy Shapiro
Resource Type: Journal article
Publication Details: Journal of pediatric hematology/oncology, Vol.31(7), pp.516-521
DOI: 10.1097/MPH.0b013e3181a6e030
PMID: 19564749
ISSN: 1077-4114
eISSN: 1536-3678
Language: English
Date published: 07/2009
Academic Unit: Stead Family Department of Pediatrics; Hematology/Oncology
Record Identifier: 9984093364002771

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