Journal article
Management of repository corticotrophin injection therapy for pulmonary sarcoidosis: a Delphi study
European respiratory review, Vol.29(155), p.190147
03/31/2020
DOI: 10.1183/16000617.0147-2019
PMCID: PMC9489143
PMID: 32198219
Abstract
In patients treated with repository corticotrophin injection (RCI) for pulmonary sarcoidosis, effective management of adverse events may improve adherence. However, management of adverse events may be challenging due to limitations in real-world clinical experience with RCI and available published guidelines.We surveyed 12 physicians with a modified Delphi process using three questionnaires. Questionnaire 1 consisted of open-ended questions. Panellists' answers were developed into a series of statements for Questionnaires 2 and 3. In these, physicians rated their agreement with the statements using a Likert scale.Key consensus recommendations included a starting dose of 40 units twice a week for patients with less severe disease, continued at a maintenance dose for patients who responded, particularly those with chronic refractory sarcoidosis. Panellists reached consensus that concomitant steroids should be quickly tapered in patients receiving RCI, but that concomitant use of immunosuppressive medications should be continued. Panellists developed consensus recommendations for adverse event management, and reached consensus that RCI should be down-titrated or discontinued if other interventions for the adverse effects fail or if the adverse effect is severe.In the absence of clinical evidence, our Delphi consensus opinions may provide practical guidance to physicians on the management of RCI to treat pulmonary sarcoidosis.
Details
- Title: Subtitle
- Management of repository corticotrophin injection therapy for pulmonary sarcoidosis: a Delphi study
- Creators
- Franck F Rahaghi - Cleveland Clinic FloridaNadera J Sweiss - University of Illinois ChicagoLesley Ann Saketkoo - Tulane UniversityMary Beth Scholand - University of UtahJoseph B Barney - University of Alabama at BirminghamAlicia K Gerke - University of IowaElyse E Lower - University of CincinnatiMehdi Mirsaeidi - University of MiamiLanier O'Hare - University of Alabama at BirminghamMark J Rumbak - University of South FloridaLobelia Samavati - Wayne State UniversityRobert P Baughman - University of Cincinnati
- Resource Type
- Journal article
- Publication Details
- European respiratory review, Vol.29(155), p.190147
- DOI
- 10.1183/16000617.0147-2019
- PMID
- 32198219
- PMCID
- PMC9489143
- NLM abbreviation
- Eur Respir Rev
- ISSN
- 1600-0617
- eISSN
- 1600-0617
- Language
- English
- Date published
- 03/31/2020
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Internal Medicine
- Record Identifier
- 9984359880502771
Metrics
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