Management of severe sepsis in the surgical patient

Kristen C Sihler; Avery B Nathens

doi:10.1016/j.suc.2006.09.005

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Management of severe sepsis in the surgical patient

Journal article

Peer reviewed

Management of severe sepsis in the surgical patient

Kristen C Sihler and Avery B Nathens

The Surgical clinics of North America, Vol.86(6), pp.1457-1481

12/01/2006

DOI: 10.1016/j.suc.2006.09.005

PMID: 17116457

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Abstract

Sepsis and septic shock are not uncommon conditions in the surgical intensive care unit. Sepsis is a generalized activation of the immune system in the presence of clinically suspected or culture-proven infection. Severe sepsis is sepsis with organ system dysfunction. Septic shock is sepsis with hypotension (systolic blood pressure <90 mm Hg) without other causes. Although the incidence of sepsis is increasing, the case fatality rate is falling. This improvement in outcome is in part due to bold initiatives like the Surviving Sepsis Campaign from the Institute for Health Care Improvement. In this article the authors present the epidemiology of severe sepsis and evidence-based campaigns for its treatment, with a focus on the surgical patient.

Acute Kidney Injury - physiopathology

Analgesia

Blood Transfusion

Clinical Protocols

Conscious Sedation

Critical Care

Fluid Therapy

Glucocorticoids - therapeutic use

Humans

Inflammation - physiopathology

Peptic Ulcer - prevention & control

Protein C - physiology

Resuscitation

Sepsis - epidemiology

Sepsis - physiopathology

Sepsis - therapy

Surgical Procedures, Operative

Treatment Outcome

Vasoconstrictor Agents - therapeutic use

Details

Title: Subtitle: Management of severe sepsis in the surgical patient
Creators: Kristen C Sihler - University of Michigan–Ann Arbor
Avery B Nathens - Harborview Medical Center
Resource Type: Journal article
Publication Details: The Surgical clinics of North America, Vol.86(6), pp.1457-1481
DOI: 10.1016/j.suc.2006.09.005
PMID: 17116457
ISSN: 0039-6109
eISSN: 1558-3171
Language: English
Date published: 12/01/2006
Academic Unit: Surgery
Record Identifier: 9984746168402771

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7 Times Cited - Web of Science