Journal article
Management of the patient with statin intolerance
Current atherosclerosis reports, Vol.12(1), pp.48-57
01/2010
DOI: 10.1007/s11883-009-0077-8
PMID: 20425271
Abstract
Current guidelines recommend statins as first-line therapy for reducing low-density lipoprotein cholesterol (LDL-C) and preventing cardiovascular events. Patients taking statins frequently experience adverse effects during therapy. The first step is to determine whether the adverse effects are indeed related to statin therapy by statin dechallenge and rechallenge. Strategies for managing statin intolerance include changing statins, intermittent dosing, intensification of lifestyle modifications, and using other LDL-C-lowering agents such as ezetimibe, bile acid sequestrants, and LDL apheresis in suitable patients. More controversial approaches include red yeast rice, coenzyme Q10, and vitamin D supplementation. New therapies for LDL-C lowering are in development.
Details
- Title: Subtitle
- Management of the patient with statin intolerance
- Creators
- Byron F Vandenberg - Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA. byron-vandenberg@uiowa.eduJennifer Robinson
- Resource Type
- Journal article
- Publication Details
- Current atherosclerosis reports, Vol.12(1), pp.48-57
- Publisher
- United States
- DOI
- 10.1007/s11883-009-0077-8
- PMID
- 20425271
- ISSN
- 1523-3804
- eISSN
- 1534-6242
- Language
- English
- Date published
- 01/2010
- Academic Unit
- Radiology; Epidemiology; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9983995145402771
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