Manganese and Lipoflavonoid Plus(Â®) to Treat Tinnitus: A Randomized Controlled Trial

Eveling Rojas-Roncancio; Richard Tyler; Hyung-Jin Jun; Tang-Chuan Wang; Haihong Ji; Claudia Coelho; Shelley Witt; Marlan R Hansen; Bruce J Gantz

doi:10.3766/jaaa.15106

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Manganese and Lipoflavonoid Plus(Â®) to Treat Tinnitus: A Randomized Controlled Trial

Journal article

Peer reviewed

Manganese and Lipoflavonoid Plus(Â®) to Treat Tinnitus: A Randomized Controlled Trial

Eveling Rojas-Roncancio, Richard Tyler, Hyung-Jin Jun, Tang-Chuan Wang, Haihong Ji, Claudia Coelho, Shelley Witt, Marlan R Hansen and Bruce J Gantz

Journal of the American Academy of Audiology, Vol.27(8), pp.661-668

09/2016

DOI: 10.3766/jaaa.15106

PMID: 27564443

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Abstract

Several tinnitus sufferers suggest that manganese has been helpful with their tinnitus. We tested this in a controlled experiment where participants were committed to taking manganese and Lipoflavonoid Plus(®) to treat their tinnitus. Randomized controlled trial. 40 participants were randomized to receive both manganese and Lipoflavonoid Plus(®) for 6 months, or Lipoflavonoid Plus(®) only (as the control). Pre- and postmeasures were obtained with the Tinnitus Handicap Questionnaire, Tinnitus Primary Functions Questionnaire, and tinnitus loudness and annoyance ratings. An audiologist performed the audiogram, the tinnitus loudness match, and minimal masking level. Twelve participants were dropped out of the study because of the side effects or were lost to follow-up. In the manganese group, 1 participant (out of 12) showed a decrease in the questionnaires, and another showed a decrease in the loudness and annoyance ratings. No participants from the control group (total 16) showed a decrease in the questionnaires ratings. Two participants in the control group reported a loudness decrement and one reported an annoyance decrement. We were not able to conclude that either manganese or Lipoflavonoid Plus(®) is an effective treatment for tinnitus.

Manganese - therapeutic use

Tinnitus - drug therapy

Humans

Middle Aged

Female

Male

Surveys and Questionnaires

Treatment Outcome

Flavonoids - therapeutic use

Details

Title: Subtitle: Manganese and Lipoflavonoid Plus(Â®) to Treat Tinnitus: A Randomized Controlled Trial
Creators: Eveling Rojas-Roncancio - Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, IA
Richard Tyler - Department of Communication Sciences and Disorders, University of Iowa, Iowa City, IA
Hyung-Jin Jun - Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, IA
Tang-Chuan Wang - Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, IA
Haihong Ji - Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, IA
Claudia Coelho - Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, IA
Shelley Witt - Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, IA
Marlan R Hansen - Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, IA
Bruce J Gantz - Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, IA
Resource Type: Journal article
Publication Details: Journal of the American Academy of Audiology, Vol.27(8), pp.661-668
DOI: 10.3766/jaaa.15106
PMID: 27564443
NLM abbreviation: J Am Acad Audiol
ISSN: 1050-0545
eISSN: 2157-3107
Publisher: American Academy of Audiology; United States
Language: English
Date published: 09/2016
Academic Unit: Communication Sciences and Disorders; Molecular Physiology and Biophysics; Neurosurgery; Otolaryngology
Record Identifier: 9984007289302771

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