Journal article
Manipulation of Cellular Redox Parameters for Improving Therapeutic Responses in B-Cell Lymphoma and Multiple Myeloma
Journal of cellular biochemistry, Vol.113(2), pp.419-425
02/2012
DOI: 10.1002/jcb.23387
PMCID: PMC3374635
PMID: 21956712
Abstract
Developing novel combined-modality therapeutic approaches based on understanding of the involvement of redox biology in apoptosis of malignant cells is a promising approach for improving clinical responses in B-cell lymphoma and multiple myeloma. Therapeutic modalities that generate reactive oxygen species (i.e., radiation, photodynamic therapy, and specific chemotherapeutic drugs) have been shown to be selectively cytotoxic to malignant B-cells. In this review, we will discuss agents that induce apoptosis in B-cell tumors by oxidative stress. Subsequently, a novel biochemical rationale (based on fundamental differences in cancer vs. normal cell oxidative metabolism) for combining oxidative stressors with radiotherapy and chemotherapy, that may lead to designing of more effective treatment strategies for B-cell malignancies, will be discussed. Besides providing potential curative benefit, such novel therapies could also selectively target and inhibit the emergence of drug-resistance in tumor cells, which is a major determinant of treatment failure in many B-cell malignancies.
Details
- Title: Subtitle
- Manipulation of Cellular Redox Parameters for Improving Therapeutic Responses in B-Cell Lymphoma and Multiple Myeloma
- Creators
- Apollina Goel - Free Radical and Radiation Biology Program, Department of Radiation Oncology, The Holden Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa 52242Douglas R Spitz - Free Radical and Radiation Biology Program, Department of Radiation Oncology, The Holden Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa 52242George J Weiner - Department of Internal Medicine, The Holden Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa 52242
- Resource Type
- Journal article
- Publication Details
- Journal of cellular biochemistry, Vol.113(2), pp.419-425
- DOI
- 10.1002/jcb.23387
- PMID
- 21956712
- PMCID
- PMC3374635
- NLM abbreviation
- J Cell Biochem
- ISSN
- 0730-2312
- eISSN
- 1097-4644
- Grant note
- R01 CA127958 || CA / National Cancer Institute : NCI
- Language
- English
- Date published
- 02/2012
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Pathology; Pharmaceutical Sciences and Experimental Therapeutics; Radiation Oncology; Internal Medicine
- Record Identifier
- 9984047614402771
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